Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.

Science, Leiden Academic Centre for Drug Research (LACDR)

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Leiden physicists have developed a way to address how accurately a superconducting single photon detector (SSPD) can be characterized by detector tomography. SSPDs are not fully understood, and tomography is a key element to determine how these devices detect light. A better understanding of these detectors…

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

The “harpe organisée”, 1720-1840: Rediscovering the lost pedal techniques on harps with a single-action pedal mechanism, is the title of Maria Christina Cleary's PhD thesis. This is the first monographic study on harp pedal techniques, tracing the historical way to pedal on the early pedal harps with…

Our group explores the larger domain of quantum measurement. In particular we investigate two themes that are closely connected: The detection of specially prepared quantum states of light and understanding and characterizing quantum photon detectors.

Promotor: J. Zaanen

Leiden physicists have managed to detect a single molecule called dibenzoterrylene in a new crystal, and found that it is a candidate component for a quantum network. Future quantum computers will need such a network to work together while maintaining their advantages. Publication in ChemPhysChem jo…

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

Lecture

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

The Joan Van der Waals colloquium is an ongoing bi-weekly lecture series.

It's pretty hard to spot a single 5 nanometer particle. Leiden physicists pulled it off by turning a 120 nm gold rod into a detector.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Caspar van den Berg was asked by Dutch news programme EditieNL for a reaction to the new coalition agreement and the ministerial team. Some ministries are set to have two ministers. Can that go well? View the excerpt.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

We, as LUGO, believe that with simple everyday actions we can prevent large amounts of single-use plastic water bottles from entering our oceans.

Scientists need individual photons for quantum cryptography and quantum computers. Leiden physicists have now experimentally demonstrated a new production method. Publication in Physical Review Letters on July 23rd.

The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.

Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Apart from his activities as coordinator of the Academy of Creative and Performing Arts, Rogier Schneemann is co-founder, guitarist and composer of the Dutch-Italian group Azure Hiptronics, originally formed in 2006.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Individual molecules are extremely hard to see through feeble fluorescence. Tiny gold nanorods serve as new antennas to intensify their signal 500 times. Publication on 24 February in Angewandte Chemie.

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

Publication in Proceedings of the National Academy of Sciences.

Promotores: G.W. Canters, T.J. Aartsma

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

The last blog of Leiden Law Blog of 2018 was written by Ladislav Kováč. He discusses the proposal for the Single-use Plastics Directive of the EU which was agreed upon on 19 December.

Paleobotanist Menno Booi discovered that 250 previously described fossil tree species are objectively not distinguishable; they belong to only one single species.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

This book project explores the changing dynamics of marriage and family life in postwar Japan based on an examination of the life histories of single mothers.

Materials are either gas, liquid or solid, based on how their molecules respond to temperature and pressure. But what if the building blocks are self-spinning particles instead of ordinary molecules? Theoretical physicists found out what determines the phase of those artificial materials. Publication…

Emily den Boer of LAPP visited the Canal Cups Expo, displaying the plastic cups cleaned up by students after Leidens Ontzet.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska