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How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

Part of ‘Moralising Misfortune: A Comparative Anthropology of Commercial Insurance’, an ERC Consolidator project of Erik Bähre.

This dissertation derives from the development of tools for algorithmic composition which extract pitch materials from sound signals, analyzing them according to their timbral and harmonic properties, putting them into motion through diverse rhythmic and textural procedures.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

What are the functions of the endocannabinoid system?

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Here are some systems and infrastructures that are useful to students.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Every year, Leiden University welcomes some 27,000 students from 115 different countries. In educating these students, we are committed to ensuring that the quality of our tuition meets or exceeds the highest-possible standards.

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

The research of our group is centered around dynamical systems, functional analysis and their interplay.

Making systems biology modelling a central pillar of research in biology

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

How can the Dutch Sand Motor strengthen our coasts in a natural way? And how can this knowledge and experience help prevent coastal erosion in Jamaica? Researchers Alexander van Oudenhoven (Institute of Environmental Sciences Leiden) and Arjen Luijendijk (Delft University of Technology) have compiled…

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

How do balanced lethal systems originate and persist in nature?

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Across many decision-making tasks, people and animals systematically repeat (or alternate) their choices - even when the choices they make are intrinsically uncorrelated. This phenomenon (also known as 'sequential effect' or 'choice hysteresis') has been known for at least a century, and may be a stable…

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

Duality, stochastic processes