In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

A full overview of MCBIM PhD theses.

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Promotor: Peter Stevenhagen

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Essays in Archaeology and Assyriology Dedicated to Diederik J.W. Meijer in Honour of his 65th Birthday

In 2013, Sylvestre Bonnet received an ERC Starting Grant to kill cancer with molecules that can be activated by light. Two postdocs and three PhD students later, the end approaches of his so far successful project.

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

We study the physics of a broad range of biological and soft materials

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Hetterscheid

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Promotor: Prof.dr. M. Ubbink

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Social Aspects of Space in the Configurational Architecture of Frankish Castles in the Holy Land, 1099-1291

The Vrijthof excavations (1969-1970)

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. E. Bouwman

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

PhD Defence

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

PNAS publication on protein encounter complexes

Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?

Promotor: Prof.dr. M. Ubbink

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.