Promotor: E. Bouwman, Co-promotor: S. Bonnet

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

In 2013, Sylvestre Bonnet received an ERC Starting Grant to kill cancer with molecules that can be activated by light. Two postdocs and three PhD students later, the end approaches of his so far successful project.

A full overview of MCBIM PhD theses.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

PhD Defence

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: Peter Stevenhagen

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Essays in Archaeology and Assyriology Dedicated to Diederik J.W. Meijer in Honour of his 65th Birthday

Promotor: Prof.dr. M. Ubbink

PhD Defence

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

We study the physics of a broad range of biological and soft materials

Social Aspects of Space in the Configurational Architecture of Frankish Castles in the Holy Land, 1099-1291

‘It has never been so easy to set up a Studium Generale series.’ With these words Tilman Grünewald thanked speaker Frank den Hollander, who kicked off the Studium Generale series on complex networks on Monday 20 February.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

Hetterscheid

The logic seems inescapable indeed. The bigger the population, the higher the probability it contains an Einstein. Hence, bigger populations are more likely to develop complex culture.

PhD Defence

For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disc surrounding a young star. The discovery reaffirms that the conditions that spawned the Earth and Sun are not unique in the Universe. The results are published…

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

The Vrijthof excavations (1969-1970)

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Scientists often need to make sense of complex systems without knowing the important parameters or even without access to all the information. A collaboration of network theorists, including Diego Garlaschelli (IMT Lucca/Leiden), has now published a review article in the inaugural issue of Nature Reviews…

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

PhD Defence

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.

Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…