32 search results for “ruthenium” in the Public website
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Light-activatable ruthenium-based anticancer prodrugs
Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Charge transport properties of Ru-complex molecules: the influence of humidity
I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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PhD Theses
A full overview of MCBIM PhD theses.
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Photo-activation of ruthenium-decorated upconverting nanoparticles
PhD Defence
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
PhD Defence
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Metals in Catalysis, Biomimetics & Inorganic Materials
Coordination chemistry is the chemistry of metal atoms "coordinated" by other atoms, ions or molecules. Important challenges in the research on coordination and organometallic chemistry are to understand the relation between the ligand and metal complex structures and the (catalytic) properties of the…
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
PhD Defence
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
PhD Defence
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The synthesis and biological applications of photo-activated ruthenium anticancer drugs
PhD Defence
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
PhD Defence
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Ten years ERC: Sylvestre Bonnet kills cancer with light
In 2013, Sylvestre Bonnet received an ERC Starting Grant to kill cancer with molecules that can be activated by light. Two postdocs and three PhD students later, the end approaches of his so far successful project.
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Vici for Sylvestre Bonnet: new light on cancer therapy
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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Sylvestre Bonnet receives an ERC grant for light-activated chemotherapy
Chemist Sylvestre Bonnet has received a Proof of Concept grant from the European Research Council (ERC). With the grant of 150,000 euros, Bonnet will investigate whether chemotherapy that is activated by light can be used against eye cancer.
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Is Michael Meijer the Smartest Chemist of the Netherlands?
He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…
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Dick Stufkens Prize 2017 awarded to chemist Sven Askes
The Dick Stufkens Prize 2017 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) is awarded to Dr Sven Askes. In his thesis
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Sense Jan van der Molen Lab (Physics of Quantum Materials)
In our lab, we investigate the physics and material properties of low-dimensional systems.
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Humidity switches molecular diode off and on
An international group of scientists, led by Leiden physicist Sense Jan van der Molen, has developed the first switchable molecular diode. You can turn this on and off through humidity. Vice versa, it is a humidity sensor at the nanoscale. Publication on 4 December in Nature Nanotechnology.
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Rik Mom receives an NWO Tenure Track and returns to Leiden
Through an NWO grant, chemist Rik Mom has received a tenure track position at the Leiden Institute of Chemistry, where he obtained his PhD cum laude in 2017. Mom will study the storage of sustainable energy by means of splitting water. Using new methods, he will investigate on an atomic scale which…
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New insight brings sustainable hydrogen one step closer
Leiden chemists Marc Koper and Ian McCrum have discovered that the degree to which a metal binds to the oxygen atom of water is decisive for how well the chemical conversion of water to molecular hydrogen takes place. This insight helps to develop better catalysts for the production of sustainable hydrogen,…
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MCBIM Mini symposium: Inorganic Tools in Life Sciences
Lecture
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The healing power of light
Light makes us flourish – in this respect we humans are just like a rose or an azalea. Light can also be used to treat people who are ill. In Leiden, Sylvestre Bonnet and Esther Habers are working – each in their own discipline – on new applications of light in a clinical context.
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Protein Surface Recognition Using Designed Molecules
Lecture
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FRESH Lecture: NikA as versatile protein scaffold for the design of artificial oxidases/oxygenases for sustainable chemistry
Lecture