The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

Rosemary's Baby is one of the greatest movies of the late 1960s and one of the best of all horror movies, an outstanding modern Gothic tale. An art-house fable and an elegant popular entertainment, it finds its home on the cusp between a cinema of sentiment and one of sensation.

Dionysius of Halicarnassus and Augustan Rome: Greek culture in the Roman world.

Mobility, Globalisation, and Interculturality is one of the six research themes of the LUCAS Modern and Contemporary cluster.

Why do communities form militias to defend themselves against violence during civil war? Using original interviews with former combatants and civilians and archival material from extensive fieldwork in Mozambique, Corinna Jentzsch (Leiden University Institute of Political Science) explains the timing,…

How do young people pursue their interests in and across multiple contexts while participating in tailor-made programs in vocational education and training (VET) and social enterprises to regain perspective in school and work?

Unlike most city histories, this book focuses exclusively on the city’s connections with colonialism and slavery.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

To be able to measure small forces or small deviations from Boltzmann, the external vibrations at the resonance frequency must be very low. To achieve this, we have developed a very soft vibration isolation system and combine it with several other measures to reduce vibrations in our dilution refrigerators.…

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

Promotor: Bas Edixhoven, Promotor: Qing Liu

Source: Eur J Med Chem (2015)

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

The aim of ANCIENT CHARM was to develop neutron-imaging techniques and the associated equipment, and help establish neutron imaging as a mainstream archaeological analytical technique. In particular, one of the goals was a new imaging technique which called neutron resonant capture imaging combined…

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

The research programme Cities, Migration and Global Interdependence 1350-2000 (CMGI) focuses on urbanisation, migration, and economic development in a comparative and global context.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

The Modern and Contemporary Cluster is the largest within LUCAS and home to more than 100 staff members and PhD candidates. Hosting a diverse group of young and advanced scholars, it offers an especially fruitful and dynamic environment for interdisciplinary collaboration.

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

The basic concern that informs every part of the research is in wonder of what happens when sound happens as an aesthetic force. The emphasis of each query lies on the active occasion, the radical empiricism, the moment of encounter, how the sonic event comes to pass as aesthetic force.

Promotor: Prof.dr. M.A.G.J. Orrit

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

On Thursday 20 May 2021, Tania Li delivered the annual Van Vollenhoven Lecture.

Exhibition, Sound installation

Promotor: P.M. Brakefield

The Hague Program for Cyber Norms, a research program at the Institute of Security and Global Affairs, published its second policy brief, in which Dennis Broeders, Liisi Adamson and Rogier Creemers explore aspects of the relationship between China and Russia in cyberspace.

In my group (the Aarts lab) we combine or structure materials, mostly in thin film form, in such a way that the hybrid has different and novel properties or functionalities.

From 2012 onwards the primary scholarly and media focus in regard to foreign fighters has been on the large number of Westerners joining jihadist groups in Syria and Iraq. Yet, much less attention has been paid to another conflict in the ring around Europe that attracted foreign fighters: the Russo-Ukrainian…

People in the Early Bonze Age used bronze artefacts as a means of payment. This is the conclusion reached by archaeologists Maikel Kuijpers and Catalin Popa in a PLOS ONE article published on 20 January.

Finally we know for sure that there is a black hole at the centre of our own galaxy. Today, astronomers unveiled the first ever photo of Sagittarius A*, a super-massive object at the centre of the Milky Way. This picture could only be taken thanks to the cooperation of telescopes worldwide.

Former PhD, Bachelor and Master students of the Van Exter Lab

Investigating neurobiological endophenotypes of Social Anxiety Disorder

From October 2, ACPA alumnus and sound artist Budhaditya Chattopadhyay will exhibit his sound installation Expanded Object.

The fourth volume of Ex Novo has the pleasure to host Heleen van Londen, Marjo J. Schlaman, and Andrea Travaglia as guest editors of the special issue titled The Natural and The Cultural. Integrating Approaches in Landscape Heritage Management. This timely collection of peer-reviewed papers and short…

If, as the works of John Cage suggest, there is “no such thing as silence,” then what are the markers that show us we are experiencing silence? - what are the performative cues during musical silence? - what are the auditory and visual bookends of silence in performance, i.e. what anticipates and…

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

This project aims to situate the current policy concept of ‘valorization of scientific knowledge’ in historical and epistemological perspectives. Conceptual understanding of the utility of scientific practices is developed in dialogue with historical analyses of the politics of knowledge in European…

NMR theory can be tough. Luckily, most NMR theory can be visualized to aid you in understanding. The animations below show precession with a 180 degree pulse, J-coupling and T1/T2 relaxation.

PhD Defence

First author Rubin Dasgupta, PhD student at the Biophysical Organic Chemistry & Macromolecular Biochemistry groups at the Leiden Institute of Chemistry has made the cover of the June edition of Solid State Nuclear Magnetic Resonance.