Anja Groten investigates matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D)*.

Examining the therapeutic potential of new semisynthetic lipopeptide antibiotics

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Current means of fighting bacteria are no longer as good as they used to be because of antibiotic resistance. These days, people are dying from bacterial infections that could have been cured fifty years ago.

Debate, MENA Cultures and Global Aesthetics

Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.

This dissertations studies state-society relations in 1930s Turkey, focusing on the anti-veiling campaigns in the mid-1930s and aiming to understand the ways in which the Kemalist policies were received, interpreted, negotiated, compromised and/or resisted by various actors in the provinces.

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

Arts and culture

PhD defence

PhD defence

A novel in vivo model system for studies on glucocorticoid resistance

PhD defence

PhD defence

PhD defence

German scientists and NASA have developed a bacteria-killing coating for space toilets. With this coating they hope to protect astronauts in space stations from pathogens. Professor of Biological chemistry Nathaniel Martin sheds light on the discovery: 'You don't expect nasty bacteria up there, but…

Lecture

PhD defence

Zaanen

Can new variants of daptomycin and the polymyxins be found?

Despite the wealth of historical literature on the Second World War, the subject of religion and churches in occupied Europe has been undervalued.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

This dissertation explores matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D).

Leiden University was founded in 1575, thanks to William of Orange. According to tradition, he founded the University to reward the citizens of Leiden for their resistance to the Spanish occupiers.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Benjamin Marius Telders, professor of international law, died of typhus in Bergen-Belsen on 6 April 1945. He was an example of civil courage before and during the occupation. He spoke up against inequity and injustice.

Leiden University has a long tradition in the collaboration with Indonesia. For Leiden’s scholars in a wide range of disciplines, Indonesia’s biological, ecological, linguistic and religious diversity, its legal system, its emerging political role, its history and its people are an important object…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

How do plant defense genes get activated?

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Globally, the number of deaths from infections is on the rise as more bacteria become resistant to antibiotics. New classes are desperately needed. A promising resistance inhibitor is now being developed by the research group of Nathaniel Martin, Professor of Biological Chemistry. Inaugural speech on…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

This book explores how ‘crisis’ - as a narrative, concept, grammar, and experience - structures time and space.

A vaccine based on sugar coats does have the potential to combat a multi-resistant staphylococcus. That is what Jeroen Codée and his colleagues from Utrecht state in Nature. In doing so, they are contradicting the earlier conclusions of German colleagues.

Key publications of the Quantitative Pharmacology group

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

Leiden University commemorates its victims of the war and pays tribute to all members of the university community who resisted injustice. Rudolph Cleveringa, for instance, the dean of the law faculty who gave a protest speech in 1940 after his Jewish colleagues were fired. We honour their memory through…

How can Staphylococcus aureus bacteria subvert the host immune system?

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

This network brings together scholars whose work explores how contemporary frameworks of crisis produce experiences of the present, rehash or disrupt established narratives of the past, and broker specific outlooks on the future. We collaborate in studying these crisis-scapes and exploring how they…