Professor Wim Willems of the Centre for Modern Urban Studies (MUS), together with Anne van Mourik, is researching the life of Ru Paré, the woman who saved 52 Jewish children during World War II.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

To eat or get eaten. It describes the evolutionary race of snakes versus the mammals and birds that prey on these snakes. Muzaffar Ali Khan devoted his PhD to investigating the molecular mechanisms play of the evolutionary arms race, and has his promotion 16 February. What makes mammals and birds successful…

Researchers from the Plant Ecology and Phytochemistry group at the Institute of Biology Leiden (IBL) received an STW (Stichting Technologische Wetenschappen) grant for applied studies in plant herbivore resistance with potential for a novel resistance test.

Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…

Does a snake die when it bites its lip? Why will a mongoose survive a scorpion’s sting, but we humans perish? These questions occupied the minds of toxin-enthusiasts and Master’s students Biology Jory van Thiel and Roel Wouters. They collected information from many sources and published their findings…

Stories of resistance in the Second World War are widely covered in Dutch historiography: Hannie Schaft, Erik Hazelhoff Roelfzema, and Professor Cleveringa are some of the best known. But these accounts largely focus on the Dutch domestic perspective. On the other side of the world, a complex colonial…

To mark its 75th anniversary, the Netherlands War Graves Foundation is publishing a portrait of a war victim every week this year. On 24 January the drawing of Irawan Soejono, a Leiden student and Indonesian resistance member, was unveiled at the Groenesteeg cemetery in Leiden, the place where Soejono…

De Verbranders, a podcast produced by PhD candidates Neske Baerwaldt (FdR/VVI) and Wiebe Ruijtenberg (FSW/CAOS), is online! You can now listen to the first episode on Soundcloud, Spotify, and Apple Podcasts. Episodes of the podcast will be introduced in various courses this year.

Book publication 'Artistic Research in Music: Discipline and Resistance' marks the 20th anniversary of the Orpheus Institute..

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Current antibiotics only address very few target proteins in bacteria to kill them. Researchers know that there are more possible target proteins to tackle the bacteria. The question is: which ones. Thanks to the NWO Vidi Grant, Assistant Professor Molecular Physiology Stephan Hacker and his team can…

In the upcoming months, PhD candidates Neske Baerwaldt (FdR / VVI) and Wiebe Ruijtenberg (FSW / CAOS) will produce the ethnographic podcast series ‘Grensverhalen’. The series will be published online in September, and will be used as teaching material in various courses.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

Lecture

PhD defence

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

Lecture, Studium Generale

What is the role of local authorities and communities in shaping how inter-Schengen borders are understood and dealt with?

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

Can we make a better vancomycin?

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Natural product inspired antibiotics to address resistance

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

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An overview of Quantitative Pharmacology projects

This year, two Leiden master students will be awarded a KNMP Student Award. Both Wisse van Os and Jip Linthorst will receive 1,000 euros from the Royal Dutch Pharmacists Association (KNMP) as a reward for their excellent study results, motivation and commitment.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

In 1940 the Germany occupiers ordered the dismissal of all Jewish staff of the university. This resulted in protest speeches by fellow academics.

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.

Antibiotic resistance is one of the major threats to human health. This week the National Antibiotic Development Platform, NADP, was officially launched via a meeting in Utrecht, with many of the stakeholders in the field present.

Can drug screening for tuberculosis treatment be made more efficient?

Conference