Prof. Marcel Reinders is a data science specialist at Delft University of technology. Using smart algorithms, he searches for links in complex data. For example, he studies patterns in DNA that lead to aberrant cell behaviour. This knowledge will help detect serious diseases such as Alzheimer's and…

How do museum visitors interpret the authenticity of museum objects? How can we support visitors' meaningful interactions with real objects?

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…

In Quantum mechanics, particles can be in multiple positions simultaneously. Yet, when a measurement is made, the particle is found only in one place. Technology has come to a point where we may design experiments that will tell us how.

Lecture

Leiden physicists have managed to detect a single molecule called dibenzoterrylene in a new crystal, and found that it is a candidate component for a quantum network. Future quantum computers will need such a network to work together while maintaining their advantages. Publication in ChemPhysChem jo…

Explaining cutback management strategies in public sector organisations: change leadership in times of crisis. How does the publicness of organisations affect the choice and implementation of cutback management strategies?

By studying language you can reconstruct the history of different communities, even when no other historical sources, such as written documents, are available. In the coming years, researchers Willem Adelaar and Marian Klamer will be carrying out this kind of reconstruction in areas of great linguistic…

Promotor: S.M. Verduyn Lunel

1) How natural cycles and activities are interconnected for building the time in one community? 2) What perceptions of Ñuu Dzaui peoples about their landscape can be connected with precolonial times?

PhD Defence

How is structural and functional brain development related to behavioral change in cognitive-control, impulse regulation, and socio-emotional functioning?

Public organizations have been confronted with severe budget cuts as a result of the most recent crisis. Public managers are tasked with the implementation of cutbacks. Using different case studies within Dutch ministries and the prison sector, we assess public managers’ change leadership in times of…

SAILS organises regular events such as symposia, webinars and workshops. We are organising virtual meetings until further notice.

The Joan Van der Waals colloquium is an ongoing bi-weekly lecture series.

Promotores: Prof.dr. J. Zaanen & Prof.dr. K.E. Schalm

Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.

Quantum computing is a novel paradigm for computation, which is nearing real-world impact with the coming generation of limited, but nonetheless powerful quantum devices.

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Promotor: Prof.dr. F.S. de Boer

On 21 March The Netherlands Centre for Electron Nanoscopy (NeCEN) hosted the Life Sciences Café. Around 60 people from neighbour companies from the Leiden BioScience Park visited the facility for cryo-electron microscopy to get a glimpse behind the scenes. Head of NeCEN Ludo Renault believes it was…

The English language and culture study programme also exists in the form of a part-time programme.

Inaugural Lecture

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Promotor: J. A. Bouwstra

Wen Yang is our Institute of Biology Leiden's nominee for the C.J. Kok Jury Award 2020.

As an alternative to the diving board shaped force sensor, we are now developing a magnetically levitated small superconducting particle – or ‘Lead Zeppelin'' – as our mechanical resonator. We explore routes towards detection of gravity between small objects.

Our cantilevers have a low intrinsic damping rate: this enables us to measure with low noise, since damping is proportionate to noise. However, when the magnet is close to the surface of a sample we want to study, we measure a much higher effective damping rate. This is caused by magnetic interaction…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

Promotor: M.A.G.J. Orrit

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: A. Kros

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This meeting will be devoted to recent advances in the operando investigation of reactivity at surfaces from both experimental and theoretical points of view.

Some species of proteins which can form liquid-like condensates, also exhibit growth into fibers (or fibrils). One particularly interesting set of such proteins are those that are associated with neurodegeneration in which the fiber growth may be related to the pathological fibrils observed in disea…

This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.