2,376 search results for “real time microscopy” in the Public website
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Evolution of bacterial movement revealed
An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.
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Michel Orrit and Hermen Overkleeft members KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.
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Interactions in Designer Materials Unveiled
Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
PhD Defence
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Time Schedule 2022
Time schedule
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Drug Discovery and Safety (MSc)
The master's specialisation Drug Discovery and Safety at Leiden University provides students with research-oriented education into the discovery of new drug targets and new lead molecules, particularly in the field of cancer, through a combination of advanced imaging techniques (‘systems microscopy’),…
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Working in intensive care: ‘You can make a real difference here’
Many alumni are frontline health workers and are working day and night to treat thousands of corona patients. Intensivist Michael Frank (53) is one of them. As head of intensive care at the Albert Schweitzer Hospital in Dordrecht, he is steering his department through the corona crisis.
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Time and memory
A study concerning the collective memory in the region of the Bene lo Ya/ Ene lo I'ya, Sierra Norte, Oaxaca.
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Magnetic Resonance Force Microscopy and the Spin Bath
PhD Defence
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eV-TEM: Transmission Electron Microscopy with few-eV Electrons
PhD Defence
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
PhD Defence
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Probing quantum materials with novel scanning tunneling microscopy techniques
PhD Defence
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
PhD Defence
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Single molecules show promise to optically detect single electrons
Optical detection of a single electron using a single molecule has never been done. Leiden physicist Michel Orrit and his team have now identified a molecule that is sensitive enough to detect an electron at a distance of hundreds of nanometers. The results are published as a cover article in ChemPh…
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Mining Sensor Data from Complex Systems
Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe
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Formulation of biopharmaceuticals
Formulation of biopharmaceuticals
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Biomedical Imaging
The rapid advances in imaging technology enable to see inside the body with ever increasing detail.
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Discovery of metastasis promoting candidate drug targets
Discovery of metastasis promoting candidate drug targets
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Crystal Cave
X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.
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Equipment (Microscopes)
The cell observatory equipment is hosted by several institutes. Each of the institutes maintain their own instruments A detailed list of equipment can be found below per institute
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Time for mapping. Cartographic temporalities
Understanding the temporal modes of digital mapping.
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Times fade away
The neolithization of the southern Netherlands in an antropological and geographical perspective
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‘It’s a real balancing act for doctors at gender clinics’
Do young people who want to change gender have the unconditional right to medical treatment? Pediatric Endocrinologist Martine de Vries, who is also Professor of Medical Ethics, treats transgender children and adolescents. She will discuss this in her ‘Pride Talk’ on 18 September.
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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Setup: MRFM
MRFM combines the principles of magnetic resonance and atomic force microscopy.
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Cum laude on understanding catalysts under extreme conditions
Physical chemist Rik Mom developed a revolutionary way to investigate catalysts in action in detail. For this work he received the distinction cum laude during his PhD defence on 29 June.
- liquid copper: an operando surface X-ray diffraction and optical microscopy study
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa
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Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.
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The Derivational Timing of Ellipsis
This volume explores the nature of ellipsis, the core phenomenon that results in various types of omission in sentences.
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Time and Identity in Indigenous Narrative and Aesthetic Strategies
This research hopes to contribute to social awareness of the consequences of colonialism for Indigenous Peoples, to the deconstruction of still existing colonial and discriminatory notions and to a better appreciation of Indigenous art and thought.
- Jan van Ruitenbeek Lab (Atomic and Molecular Conductors)
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Vibration Isolation
To be able to measure small forces or small deviations from Boltzmann, the external vibrations at the resonance frequency must be very low. To achieve this, we have developed a very soft vibration isolation system and combine it with several other measures to reduce vibrations in our dilution refrigerators.…
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Working at the Faculty of Science
Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.
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Kraft Lab (Self-assembly in Biological and Soft Matter)
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
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Stefan Semrau Lab (Quantitative Single-Cell Biology)
We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.
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Our technology: Cathodic Corrosion Method (CCM)
Cathodic corrosion for producing nanoparticles was (re)discovered when trying to control the electrochemical etching of a scanning tunneling microscopy (STM) tip.
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The added risk of size
What are the risks of nanoparticles?
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:
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Centre for Interdisciplinary Genome Research
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Healthy University “Time to Recharge” Week
It’s Healthy University Week at Leiden University and the LUMC from 25 to 29 October. A week full of activities to help our staff stay physically and mentally fit. Join our daily online energisers, follow a lunchtime lecture or register for one of our workshops.
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(Un)timely Crises Chronotopes and Critique
This book explores how ‘crisis’ - as a narrative, concept, grammar, and experience - structures time and space.
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Regulating Working Conditions in Times of Globalization
On 28 June 2018, Qiuyin Hu defended his doctoral thesis 'Regulating Working Conditions in Times of Globalization'. The doctoral research was supervised by Prof.dr. G.J.J. Heerma van Voss and Prof. dr. B. Barentsen.
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(Un)timely Crises: Chronotopes and Critique
Un)timely Crises explores how ‘crisis’—as a narrative, concept, grammar, and experience—structures time and space. This collectively written volume extends Bakhtin’s ‘chronotope’ to challenge mobilizations of crisis within neoliberal governmentality. The book explores how contemporary crises can trigger…
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Medical Delta professor Marcel Reinders: ‘You need collaboration to make a real impact’
Prof. Marcel Reinders is a data science specialist at Delft University of technology. Using smart algorithms, he searches for links in complex data. For example, he studies patterns in DNA that lead to aberrant cell behaviour. This knowledge will help detect serious diseases such as Alzheimer's and…