The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Political scientists Huib Pellikaan and Niels van Willigen (Leiden University) use and elaborate on the theoretical insights from game theory in order to understand nuclear security in changing environment. Now that the relations between the US and Russia have deteriorated and smaller nuclear states…

PhD Defence

If you are intrested instudying stochastics, the following information will help you to choose the right path

Every summer, Leiden University is the setting of dozens of summer schools in which professionals and students can receive extra training on a specific topic within a short space of time. We took a look at a summer programme on extremism. ‘A recruiter for al-Qaeda said that I could change the world.…

VIPP/VIPP-SD (the basic module) can be applied to most family situations. However, some modules have been adapted to suit specific target groups. After completing the four-day basic training for the VIPP-SD, professionals can be trained to apply these specific modules. We work together with various…

Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs at Leiden University, can be heard in the latest Podcast of Wetenschap.nu.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs, appeared as guest on VICE to discuss the usefulness of recent ban on QAnon.

There are a number of problems in philosophy that seem to share a similar possible solution: 'Why do promises and contracts bind?', 'Why ought citizens and judges obey the law?' and 'Can we realize the gains to be made from cooperation?'. All three problems (as well as some others) share a possible…

An interdisciplinary cultural analysis of how the Hindustani double migration informs contemporary processes of identification and problematises the juxtaposition of tradition and modernity.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Promotor: Robert Tijdeman, Co-promotor: Cornelis Kraaikamp

PhD Defence

The Encyclopedia of Global Human Migration provides a complete exploration of the prominent themes, events, and theoretical underpinnings of the movements of human populations from prehistory to the present day.

Promotor: A. Doelman, Co-promotor: M.F.E. de Jeu

Professor Edwin Bakker, director of the Centre for Terrorism & Counterterrorism, released his new book “Terrorism and Counterterrorism Studies: Comparing Theory and Practice”, published by Leiden University Press.

Article in the journal Irish Political Studies discussing the challenge of aggregating opinion polls and presenting a method to better model major sudden political and societal events. This can can enhance opinion poll reporting in the media.

Mission statement

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

While colloidal aggregates are often undesirable due to their random shapes, we exploit them as a starting point to synthesize patchy particles.

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

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How are the epidermal lipid pathways involved in health and disease.

Leiden University provides ambitious students with the most recent and innovative areas of knowledge, and offers them the freedom to develop their own area of expertise.

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

Promotor: J. A. Bouwstra