This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacological mathematical and statistical (pharmacometrics) modeling combined with systems biology modeling approaches, to characterize biomarkers for of disease and treatment…

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

Promotor: T. Schmidt

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Research impact is measured in different ways. However, these indicators are often based on dubious calculations, says Ludo Waltman. Inaugural lecture on 21 June.

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Science, Leiden Institute of Advanced Computer Science (LIACS)

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

PhD Defence

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Course

Fokelien Kootstra defended her thesis on 23 April 2019

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Research at the department of Environmental Biology

As a leading research, consulting, and training center, CWTS is dedicated to increasing our understanding of scientific quality, societal impact, and other related concepts. CWTS studies the conditions and consequences of research evaluation for the generation of new knowledge, and the role of research…

Ludo Waltman has been appointed as professor of Science, Technology and Innovation Studies, especially Quantitative Science Studies, at Leiden University. The chair is located at the Centre for Science and Technology Studies (CWTS).

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

The Netherlands Organisation for Scientific Research (NWO) has awarded Veni funding to two researchers from the Institute of Criminal Law and Criminology. Anke Ramakers and Hilde Wermink. This award offers these criminologists the opportunity to develop their own ideas over a period of three years.

Social and Behavioural Sciences, Political Science

Research at Leiden Law School means research at the highest level. Leiden Law School has eight broad research programmes and one specific ‘profile area’: Interaction between legal systems - which aims to understand the complex interaction between the various levels of jurisdiction and to solve the resulting…

The Institute of Political Science has a multi-dimensional research programme that promotes the unity of the institute as an intellectual community rooted in the social sciences and especially political science, while enabling overlapping groups of colleagues to develop particular research agendas within…

The members of LUXs develop and validate new methods and algorithms for analysing data, and apply these in a wide range of problems. Their research ranges from multidisciplinary applications to proving mathematical theorems.

CML researches sustainable management of natural resources, environmental quality and biodiversity in a strategic multidisciplinary manner.  Within this scope we offer two distinct research programmes: Environmental Biology and Industrial Ecology, both addressing the relations between human activities…

Governance of Sustainability is a two-year programme, worth 120 European Credit Transfer System points (ECTS).

An overview of research projects at the Predictive Pharmacology group.

Disseminating to the future generation of researchers the multidisciplinary working practices, expertise and scientific view that has been developed in research within the Plant BioDynamics Lab over the past years is an important objective in our collaborative efforts. The research papers of PBDL bring…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

Imprint of Action is the first large-scale study focussing entirely on sociocultural impact in archaeology and, as such, is explorative in nature; it provides unique insights into the workings of interaction and participation in archaeological events, and openly shares qualitative and quantitative research…

Combining results from bibliometric analyses, a global sample of researcher opinions and case-study interviews, a new report reveals that although the benefits of open research data are well known, in practice, confusion remains within the researcher community around when and how to share research…

In recent years, the use of primary data in terrorism research has increased. In order to maximise the benefits of this trend, we want to encourage terrorism scholars to implement open science practices more systematically. This article therefore presents different avenues towards open and reproducible…

A quantitative study on the use of pre-trial detention of juveniles in The Netherlands.

SLAVES TO THE SYSTEM: Locating Responsibility for Forced Expatriate Labour Practices by the Democratic People’s Republic of Korea (DPRK)

The VVI seeks to develop and disseminate socio-legal knowledge and theory regarding the interaction between law, governance and society. More specifically, the Institute studies the emergence, functioning, and evolution of legal institutions.

LCDS organises monthly seminars for researchers and anyone else interested in Data Science. Each of these meetings is centered around a specific topic or academic field, which we approach from a Data Science perspective.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

The International Relations and Diplomacy programme gives you a unique combination: a thorough academic education in international relations and political science with practice-based training in international negotiation and diplomacy.