1,000 search results for “pulsatile profiles” in the Public website
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Research projects
An overview of research themes and projects at ABS.
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African Studies (MA)
The master’s in African Studies at Leiden University is an advanced area studies qualification that combines world-class scholarship with practice-based learning.
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New cellular imaging paves way for cancer treatment
A new technique using fluorescent imaging to track the actions of enzymes might aid drug design for new anti-cancer, inflammation and kidney disease treatments. Researchers at the University of York and Leiden University have published these findings in Nature Chemical Biology.
- The Use of Activity-Based Protein Profiling to Study Proteasome Biology
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osteoarthritis and arthroplasty: from patient perspective to molecular profiling
PhD Defence
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Biochemical profiling of the brain and cerebrospinal fluid in monogenetic and multi-factorial migraine syndromes
PhD Defence
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Focus areas
Within a multidisciplinary research team, cooperation takes place on the following focus areas:
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Biotransformation of plant metabolites in microorganisms
- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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Die Partimenti von Giovanni Paisiello Ansätze zu ihrem Verständnis
This doctoral thesis focuses on Paisiello's partimenti and how to approach their realization and performance.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Congruence between voters and parties: The role of party‐level issue salience
The level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties.
- Prof Dr Consuelo De Moraes
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Natural Products Lab
We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.
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Education
The Leiden University Institute for History has a wide-ranging academic scope unique for the Netherlands. This is directly reflected in the participation of her staff in various Master's and Bachelor's programmes at Leiden University.
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LUCIR: Leiden University Centre for International Relations
International relations and organisations from different scholarly perspectives.
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Surface plasmon lasers
Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…
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Neurofibromatosis Type I
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Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…
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Career Guidance
The post-PhD phase is discussed during the many formal and informal meetings PhD candidates have with their supervisor.
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Centre for Political Philosophy
The Centre for Political Philosophy (CPP) at Leiden University is an interdisciplinary platform for political thought. It aims to bring together all those with an active interest in the field from different institutes, branches and fields of study at Leiden University.
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Key publications
Key publications of the Analytical BioSciences and Metabolomics group
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Study at LUCAS
LUCAS members are experts in the fields of literary history and theory, film and media studies, and art, architectural, and book history. Members of LUCAS teach in a wide variety of Bachelor's, Master’s, and Research Master’s Programmes.
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Cognitive and motivational components of adaptive and maladaptive decision-making: an integrative approach
How do cognitive, motivational, and affective processes interact to select actions?
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Work for third parties activities
There are strict conditions relating to work for third parties.
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Heritage encased in public and private care
Bringing Dominican indigenous collections back to the community
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Collaborative Crisis Management Before and During International Summits
Peak Performance: Collaborative Crisis Management Before and During International Summits. This comparative case study probes into conditions for collaborative governance in the security organisation of international summits.
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Conspiracy, legitimacy and violence
Can conspiracy constructions explain for hatred of the system? And if so, should conspiracy constructions be considered to be a risk in terms of national security?
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Immigrants on Grindr: Race, Sexuality and Belonging Online
This book investigates how gay-identified immigrants and refugees experience feelings of inclusion or exclusion within a sexually-charged online subculture. Explores the response of ethnic minorities to demonstrations of racism and xenophobia within an intolerant European climate. Challenges political…
- Governance and Global Affairs
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Historic Chinese Materia Medica revisited
What are the differences between the trade in Chinese herbal drugs in Europe between 1800 and now? Can we see the major metabolic changes after 200 yours?
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Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists
Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.
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Alvaro Viljoen
Professor at the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria - South Africa
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Neurogenomics of vocal learning
How does FoxP1 affect auditory perception on a behavioural and genomic level?
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Essays on trends in income distribution and redistribution in affluent countries and China
Over the last decades, income inequality has increased globally. How do social policies affect this increasing trend? How do international trade and technological progress affect inequality? What is the profile of income inequality in China?
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ACTION
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…
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The interpretation of physical activity wearable data and its relation with metabolic and brain health in older adults
Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Ana Achúcarro (The Early Universe)
We explore the particle physics and quantum world at the time of the big bang.
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Using soil inoculations for ecological restorations
How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?
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Coming Up
This Call for Proposals covers a wide range of research incubator ideas to stimulate research careers of early career female researchers at FGGA. Research incubator ideas may include various research themes and could concern different types of research projects.
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Fieldwork
Fieldwork is an essential part of this research and of course this part of the project is also a joint effort by citizen scientists and professional archaeologists. Discover when fieldwork will take place and how you can participate.
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Leukemia treatment & cognitive development
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt