Research question

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Source: J Cheminform, Volume 7, Issue 1 (2015)

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Key publications of the Computational Drug Discovery group

Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

These are CCLS events that have already taken place. PDFs of the presentations will be added once they have been received.

Drs. Lindsey Burggraaff wins KNCV poster prize in the category

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. The University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP) work…

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the

Gerard van Westen has been appointed full Professor or Artificial Intelligence and Medicinal Chemistry. This chair has been jointly created by the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institute of Chemistry (LIC) as part of SAILS, the university stimulus program in Artificial…

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

Here you can find our most recent research publications