508 search results for “proteochemometric modeling” in the Public website
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Pasteurs Cube: a new model for classifying academic researchers?
Applying a three-dimensional framework of research-related activities, Pasteur’s Cube helps to describe and study ‘use inspired’ academics at today’s research-intensive universities.
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Smartmix: A new generation of efficient biomedical research
Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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New model predicts ‘yoyo’ orbits around black holes
Stars orbit black holes while jumping up and down. This is the prediction of a theoretical model developed by Leiden physicist Satish Kumar Saravanan, based on Einstein’s theory of relativity. He defends his PhD thesis on July 7th.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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Leiden Medicinal Chemistry researcher Andreas Bender receives prestigious EFMC Prize
Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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Advances in Survival Analysis and Optimal Scaling Methods
This thesis is based on five papers on several topics.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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Sebastiaan Deetman
Science
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Ruben Huele
Science
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Mirko Forastiere
Science
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Mathilde Verdam
Faculteit der Sociale Wetenschappen
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Weilin Huang
Science
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Fulco Scherjon
Faculteit Archeologie
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Myrthe Veenman
Faculteit der Sociale Wetenschappen
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Carina Harpprecht
Science
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Dirk-Jan Kok
Science
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Jinhui Zhou
Science
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Carlotta Rieble
Faculteit der Sociale Wetenschappen
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Henk Kelderman
Faculteit der Sociale Wetenschappen
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Amie Corbin
Science
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Nicolas Navarre
Science
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Anne Uilhoorn
Science
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Micha Drukker
Science
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Bamboo
Biodiversity and trade: mitigating the impacts of non-food biomass global supply chains.
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New publication by Christa Tobler on alternative models of EU integration
Following the conference of the 20th Austrian European Law Day in September 2021 at the University of Liechtenstein in Vaduz, the academic papers of the conference have now been published in book form. The book contributions include a chapter by Christa Tobler: Christa Tobler, 'Finally Brexit - Alternative…
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MULTIPLY - MULTIscale SENTINEL land surface information retrieval Platform
Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.
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Joost Beltman
Science
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Marco Spruit wants to develop a language model to improve healthcare
By making smart use of available data, the health and care of people can be substantially improved. Marco Spruit wants to use language and machine learning in the coming years to identify and solve the biggest care issues in the region of The Hague. He has been appointed Professor of Advanced Data Science…
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dr. ir. Hai-Xiang Lin working on Data Analytics for Environmental Modelling joins CML
Prof.dr.ir. Hai-Xiang Lin is appointed on 1 March 2015 as part-time professor on Data Analytics for Environmental Modelling at CML on behalf of the R. Timman foundation. He will join the CML-department of Industrial Ecology. He has a position at the Department of Applied Mathematics at the Faculty…
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Leiden University wins best position paper at the 2019 Model ICAO
The 2019 Model ICAO took place from 21-24 May at the ICAO headquarters in Montreal.
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‘Seeing voices’: the role of multimodal cues in vocal learning
Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Weathering the Ice Age
Where did species survive the cold cycles of the current Ice Age?
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Cycling like a Jumbo-Visma pro with the Leiden data model
Just like the professional riders from the Jumbo-Visma team, amateur cyclists will soon be able to analyse and improve their performance. Leiden data scientists working with the cycling team are making their smart data model available so that every serious cyclist can keep track of their fitness.
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Mathematical model helps to explain the formation of spine and ribs
Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.
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Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
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Statistical Science
The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.