BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Key publications of the Skin Barrier and Vaccination group.

The list of highly Cited Researchers identifies the world’s most influential contemporary researchers across 21 scientific fields. Prof. dr. W. Jiskoot is cited one out of three in the field of Pharmacology & Toxicology in the Netherlands, and as one of four of all categories in Leiden.

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

During the course of drug discovery translational steps are made.

A full overview of MacBio PhD Theses.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle and Lars Jeuken.

Master projects are available in

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotores: W. Jiskoot, F. Ossendorp

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

The potential of bioneedles to deliver influenza vaccines was investigated.

Bachelor projects are available in

How do plant defense genes get activated?

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.

Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.

PhD Defence

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…