A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Lecture

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

Principles of Functional Analysis applied to Dutch Neolithic Assemblages.

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

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Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

From basic science to real-world interventions

Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…

The objective of this project is the development of a new psychometric model, called the Generalized Squared Distance Logistic Model (GSDLM). This model is an evolution of older psychometric approaches (such as PARELLA, GHCM, and GGUM) and the Gaussian Ordination Models (GOMs) used in environmental…

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

During the course of drug discovery translational steps are made.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

The ambition of the Analytical BioSciences and Metabolomics group led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies…

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

Developing methodes to understand the evolution of patches in natural ecosystems

How to improve the method in quantifying the combined effects of metal-based chemicals?

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

How can we make make accurate predictions for reactions of molecules on metal surfaces?

When applying you need to have some documents ready. Make sure you have all of them, or we cannot process your application.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Supervisor: Maarten Doornbos

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Along with your application, you will have to submit a variety of documents. This information only applies to students who need to submit an application for admission. If you have a diploma that grants you automatic admission to a bachelor’s programme, you won’t need to submit additional documents.

Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…

Can we predict fluctuations in suicidal ideation in a person’s daily life, from hour to hour?

Psycholinguistic research

This project is situated within the context of an innovation of the biology curriculum in Dutch secondary schools. The main purposes are (1) to clarify the relation between teachers’ practical knowledge and the decisions they make when planning and implementing their lessons and (2) to develop a professional…

Pharmacologist Liesbeth de Lange has won the Lewis B. Sheiner Lecturer Award from the International Society of Pharmacometrics (ISoP). As Professor of Predictive Pharmacology she is working, among other things, on a mathematical model that can predict drug concentrations in the brain. On the occasion…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

The programme group Research Methods and Statistics has a broad orientation on research. It offers support to researchers from a variety of research projects within Education and Child Studies.

On February 7th, Lotte Dros-Hendriks succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Lotte on this great result.

The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to achieve the ability to predict the outcome of chemical reactions involving hydrogen from first principles. This goal is important in almost all fields of chemistry and in many fields of physics.

PhD at Molecular Biology and Biochemistry Department, University of Malaga - Spain

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.