517 search results for “powder formulation” in the Public website
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Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars
The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.
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Biologics Formulation
The Biologics Formulation Group is led by Prof. Wim Jiskoot. A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals…
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Formulation of biopharmaceuticals
Formulation of biopharmaceuticals
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Current and next generation influenza vaccines: Formulation and production strategies
Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Development of formulation for treatment of Atopic Eczema
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supercritical fluid spray drying process for producing dry protein formulations
In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.
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Solid Bioneedle-Delivered Influenza Vaccines Are Highly Thermostable and Induce Both Humoral and Cellular Immune Responses
The potential of bioneedles to deliver influenza vaccines was investigated.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Microfluidics for high-throughput liposome formulation for personalized cancer vaccination
Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…
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Novel formulations and delivery strategies for inactivated polio vaccines: new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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dioxide spray drying for the production of stable dried protein formulations
Promotor: W. Jiskoot, Co-promotor: H.A. Every
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their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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Development of thermostable lyophilized inactivated polio vaccine
The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.
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Bram Slütter
Science
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Transforming Innovations in Africa
The authors in this volume explore how external innovations (products, technologies, services, institutions and processes) have been appropriated in African societies in order to be acceptable and relevant to local conditions, expectations and demands.
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Key publications
Key publications of the Biologics Formulation group
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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Egyptian temple oaths in Ptolemaic Egypt. A comparative approach at the crossroads of law, ethnics and religion
Een onderzoek naar de formulering, structuur, rechtshistorische aard en sociale en religieuze achtergronden van Laat-Egyptische (demotische) tempeleden, aangevuld met 70 ongepubliceerde teksten.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Innovative analytical approaches for protein aggregates and other particulate matter impurities
Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.
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Research
An overview of the research at the Biologics Formulation group
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Characterization of Cell-based medicinal products (CBMPs)
Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…
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Stijl en politiek. Een taalkundig-stilistische benadering van Nederlandse parlementaire toespraken
This dissertation contains the further development of a method for linguistic-stylistic research, which provides a systematic means to interpret global impressions of a text through choices in formulation at word- and sentence level.
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros
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A novel formulation for skin barrier Repair
PhD Defence
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Thomas Meekel
Thomas is currently a Bachelor’s student at Leiden University Law School.
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Tekstbegrip in het onderwijs klassieke talen
In this study an attempt has been made to describe the degree in which the new objectives of the school subjects Greek and Latin, as formulated at the theoretical level by institutes as curriculum planning committees, are are incorporated by the teachers in their actual teaching practice.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Buccal and sublingual vaccine delivery
Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Fuzzy systems and unsupervised computing: exploration of applications in biology
In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.
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The Modern Transformation of Korean Political Thinking: Revisiting the Political Ideas of the Late Nineteenth-Century Reformists
Choong-Yeol Kim defended his thesis on 14 November 2019
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Duidelijkheid van fiscale wetgeving
On 29 November 2018, Roberto van den Heuvel zijn defended his thesis 'Duidelijkheid van fiscale wetgeving'. The doctoral research was supervised by prof. dr. A.O. Lubbers en prof. dr. H. Vording.
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Research-based education
Didactics
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Cationic liposomes loaded with a synthetic long Peptide and poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell
For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…
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The development of an assessment procedure for beginning teachers of English as a foreign language
This dissertation reports on the requirements for the design and development of teacher assessments, and examines the possibility of developing an assessment procedure that complies with the formulated requirements.
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Novel formulations and delivery strategies for inactivated poliovirus vaccines
PhD Defence
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Analysis of sub-visible particles in complex injectable formulations
PhD Defence
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CO2-Calculator
Development of GHG calculator for bio-electricity and heat.
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Development of cross-protective influenza A vaccines based on cellular responses
Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…
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Cooperation of International Organisations in Peacekeeping Operations and Issues of International Responsibility
Can international organisations be held responsible for violations of international law by peacekeepers in a peacekeeping operation?
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…