How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

This book argues that the combined literary, epigraphic and archaeological evidence supports the theory that early-imperial Italy had about six million inhabitants.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

PhD Defence

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

Promotor: J. A. Bouwstra

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

Leiden University Medical Center (LUMC) and Leiden University will start a new two-year English-taught master’s programme in Population Health Management (PHM) on 1 September 2021. The programme, which has been given the green light by the Accreditation Organisation of the Netherlands and Flanders (NVAO),…

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Hilde Wermink, Assistant Professor at the Institute of Criminal Law & Criminology was interviewed on this topic for an article published in US News on 13 May.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

An aging population, rising healthcare costs and technical developments in the medical sector. Do you want to know the best way of dealing with current issues in healthcare? Then join the Summer Schools Population Health Management from the LUMC-Campus The Hague from the 1ste until the 5th of July.

A cultural delegation from Taiwan has presented 175 books and journals to Leiden University. The gift is meant as thanks for all the research carried out by the university on the subject of the indigenous peoples of Formosa, as Taiwan was called in the past.

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Hardly ever before have different groups in the population retreated into their own bubble as much as they are doing today. Professor of Sociology and Law Maartje van der Woude and her students will be examining the effect of social distancing on relationships. How do the people of Leiden look at students…

Mechanical interactions between cells and their environment play an important role in many biological processes.

Promotores: J. Jonkers, K.E. de Visser

Promotor: Prof.dr. G.R. de Snoo

The circular economy is typically seen as the progressive alternative to our wasteful linear economy, where raw materials are used to make the products that feed today’s rampant consumerist hunger, which are then thrown away. In a fascinating article, archaeologist Maikel Kuijpers reflects on the recycling…

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Interview with political scientist Hans Vollaard (Leiden University) about “Nexit” speculations, the strengths and weaknesses of Geert Wilders’s Party for Freedom, and the general attitude towards Europe in the Netherlands.

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.