An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Today's health care system faces many challenges. The new interdisciplinary two years master PHM will train you to contribute to a more integrated health care system.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Course

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We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

An ageing population, epidemiological challenges, rising healthcare costs, and technical developments in the medical sector: Learn about this new strategy and acquire new competences to deal with these current issues. Join the Summer school of 2021 for an excellent scientific introduction to Population…

Promotor: Roeland M.H. Merks

This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. E. Deprettere

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

Source: J Cheminform, Volume 7, Issue 1 (2015)

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

This timely and engaging book examines the rise of populism across the globe. Combining insights from linguistics, argumentation theory, rhetoric, legal theory and political theory it offers a fully integrated characterization of the form and content of populist discourse.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The master Population Health Management will equip you with the necessary competences to play a key role in the constantly changing healthcare landscape in which societal, patient and clinical results are all equally relevant.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

PhD Defence

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Peter Grunwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

ASLU 14

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

A research agenda