An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

This research line is part of the living lab of the University’s Population Health interdisciplinary program, located at the LUMC Campus The Hague, where the Leiden University Medical Center collaborates with the Faculty of Governance and Global Affairs and the Faculty of Social and Behavioral Sciences…

Today's health care system faces many challenges. The new interdisciplinary two years Master PHM will train you to contribute to a more integrated health care system.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Sebastian Diessner, Assistant Professor at the Institute of Public Administration, focuses on the role of the European Central Bank in a critical phase toward a new presidency and its approach to monetary policy by looking at both financial market and survey data.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Today's health care system faces many challenges. The new interdisciplinary two-year master's programme in Population Health Management (PHM) will train you to contribute to a more integrated health care system. Read more about the progamme on this page.

Today's health care system faces many challenges. The new interdisciplinary two-year master's programme in Population Health Management (PHM) will train you to contribute to a more integrated health care system. Read more about the progamme on this page.

Course

Course

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Is your question not on this FAQ? Please contact us for a personalised answer via: master.PHM@lumc.nl.

An ageing population, epidemiological challenges, rising healthcare costs, and technical developments in the medical sector: Learn about this new strategy and acquire new competences to deal with these current issues. Join the Summer school of 2021 for an excellent scientific introduction to Population…

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Source: J Cheminform, Volume 7, Issue 1 (2015)

Promotor: Prof.dr. E. Deprettere

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This timely and engaging book examines the rise of populism across the globe. Combining insights from linguistics, argumentation theory, rhetoric, legal theory and political theory it offers a fully integrated characterization of the form and content of populist discourse.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

The master Population Health Management will equip you with the necessary competences to play a key role in the constantly changing healthcare landscape in which societal, patient and clinical results are all equally relevant.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Arts and leisure, Arts and leisure

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Peter Grunwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

ASLU 14

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.