Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

How is the development of physiological responses to social evaluation in adolescence affected by other normative developments, such as pubertal, socio-cognitive and psychosocial development? Are social anxiety and public speaking anxiety associated with characteristic patterns of stress responses…

Promotor: P.M. Brakefield

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Promotor: Prof.dr. M. Danhof

Mario van der Stelt has been appointed Professor of Molecular Physiology at the Leiden Institute of Chemistry with effect from 1 November 2017.

Blood, Sweat and Tears: The Changing Concepts of Physiology from Antiquity into Early Modern Europe

Inaugural Lecture

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Psycho-physiological studies for health and disease.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

PhD Defence

The Molecular Physiology group collaborates with both international public-private and academic institutions.

A comparative study in the History of Modern Philosophy focused on the recourse to physiology on the part of two key figures, Spinoza and Nietzsche.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Biological and behavioural measurements of parent-child interactions.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Lecture

PhD Defence

PhD Defence

PhD Defence

Psycho-physiological reactions to stress.

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Shared, general-purpose labs.

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Observational, cognitive and physiological measurements in social contexts.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

PhD at the Max Planck Institute of Molecular Plant Physiology, Golm – Germany

How distance-dependent is graphene as biological sensor?

Contact information & address

How did toxin genes evolve from harmless physiological genes?

1. Social anxiety and factors determining school success in children. 2. Brain development in relation to cognitive, social and emotional development in adolescence

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Reading emotions from others’ faces strengthens social relationships. But how is that for children with hearing loss? Can they learn to read faces just as easily as hearing children? The study by Yung-Ting Tsou and colleagues shows that daily

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.