Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Using photosynthesis to generate energy, or using enzymes to effectively produce biofuel; Leiden chemists Huub de Groot en Hermen Overkleeft have both obtained an NWO TOP funding for their pioneering research. With the money they can take on new PhD students.

Efficient gene-targeting during meiosis

In what way can the chemical properties of cobalt porphyrines be adjusted to optimize their selectivity and activity when using them for the electrochemical conversion of CO2 to methane and methanol?

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

What are the environmental trade-offs for SMEs considering moving from monoculture aquaculture practice towards IMTA? What are the environmental trade-offs comparing IMTA species with their conventional monoculture alternatives?

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

Over time, the temperature in all buildings will be regulated in a sustainable manner. In this way, using gas will not be necessary anymore.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

On 24 November 2015, Prof. Carsten Stahn participated as external expert in a special plenary session of the Assembly of States Parties on the efficiency and effectiveness of Court proceedings, chaired by the co-chairs of the Study Group on Governance of the Assembly.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Schneider

Promotor: A. Kros

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

The recently promoted Hao Wang from the Leiden Institute of Advanced Computer Science teaches computer programmes how to solve real-world problems. His goal is to make the process of problem-solving more efficient. On 1 November, he obtained his doctorate with the predicate cum laude. ‘I hope to solve…

How does the photoregulation mechanism work in detail?

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Scientists have long been puzzled why it is easier to produce hydrogen from water in an acidic environment than in an alkaline environment. Marc Koper comes with an explanation: the reason is the electric field at the surface of the catalyst, which is larger in an alkaline environment, as he writes…

Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Research of the Leiden Institute of Chemistry into the development of a sustainable fuel cell has accidentally resulted in an exceptionally efficient catalyst for the production of hydrogen peroxide. The catalyst, discovered by Dennis Hetterscheid and PhD candidate Michiel Langerman, may lead to a more…

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Why is the swimming efficiency of the European eel higher than predicted?

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

On Tuesday 10 March 2015 - 10h Ernst Worrell, professor at the University of Utrecht with a chair on "Energy, materials & Environment", will give a lecture at CML on "Material Matter: Connecting Energy and Material Efficiency"

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

On Friday 10 July the Towards Biosolar Cells research programme was granted a budget of 25 million euros by the Dutch Government. The Ministry of Agriculture, Nature and Food Quality recommended the programme because it will contribute to green energy, improve food supplies and a create a more sustainable…

Research at the BPOC/SSNMR group is comprised of the following research themes:

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

A full overview of BPOC/SSNMR PhD theses.

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Lecture

A full overview of MacBio PhD Theses.

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…

Juurlink

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…