Science, Leiden Academic Centre for Drug Research (LACDR)

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Professor of Predictive Pharmacology Elizabeth de Lange has received an Honorary Doctorate from the Faculty of Pharmacy of Uppsala University. She will be honoured during the Uppsala Winter Conferment Ceremony on 31 January 2020.

Research lines within the Pharmacy group:

Your time at Leiden is about more than just studying. Some of your best experiences will stem from being a part of our lively and diverse student community, as well as from life in the beautiful city of Leiden.

At Leiden University, researchers from all disciplines work together to find answers and design innovations in the field of artificial intelligence.

The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

What is the role of stress and stress-related hormones in emotion regulation?

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

The research carried out within the unit Health, Medical and Neuropsychology investigates the psychological factors of health and disease, and the development of innovative treatment.

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

The Ancient Worlds Network brings together staff and graduate students in LIAS working on the ancient Mediterranean and Near Eastern world.

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Education & outreach

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

As part of the ZonMW Antibiotics resistance funding program, the LACDR cluster Systems Pharmacology was awarded €455.255 for a research project to develop novel clinical biomarkers for bacterial infections.

The list of highly Cited Researchers identifies the world’s most influential contemporary researchers across 21 scientific fields. Prof. dr. W. Jiskoot is cited one out of three in the field of Pharmacology & Toxicology in the Netherlands, and as one of four of all categories in Leiden.

Alireza Mashaghi, a principal investigator at the Division of Systems Biomedicine and Pharmacology has been appointed Adjunct Professor at the Ocular Genomics Institute of Fudan University, a leading university in China. This appointment will boost the ongoing cooperation between LACDR and Fudan University…

Meindert Danhof is the 2019 recipient of the Høst Madsen Medal for his pioneering work in systems pharmacology. He received the award on 22 September at the FIP World Congress of Pharmacy and Pharmaceutical Sciences in Abu Dhabi.

What’s the right dosage of medication for children? Assistant professor Elke Krekels and her colleagues discovered that for some medicines, you can determine this quite simply. On 13 April Krekels received the TOP-Publication award during the annual spring meeting of the Dutch Society for Clinical Pharmacology…

Predictable variation in children’s dosage Professor Catherijne Knibbe – Pharmacology There is no adequate foundation for te dosage of medicines prescribed for children in 40-80% of cases.

The Netherlands Organisation for Scientific Research (NWO) comprises several units. Eight Divisions for Sciences develop new research programmes, assess subsidy requests and monitor projects that NWO finances. ALW- Earth and Life Sciences is one of NWO’s eight Divisions for Science. Professor Melly…

Tuesday May 24th, the LACDR Annual Spring Symposium was held.

PhD student of the division Pharmacology, Jantine Brussee has won the second prize of the Figon-Pfizer PhD student Competition, at the Dutch Medicine Days in Ede.

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.

An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.

The Oncode Institute is a new international network organisation that focuses on making sure that new scientific findings on cancer are implemented in patients as rapidly as possible. Two young female researchers at Leiden University have been selected to join Oncode: Laura Heiman (Leiden Academic…

During the annual LACDR Spring Symposium, the audience chose PhD student Rob van Wijk as best speaker. Furthermore, six PhD students won a poster prize. Matthias P. Mayer of Heidelberg University opened the symposium with a keynote lecture about chaperone proteins.

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

Leiden pharmacy and pharmacology has risen to 17th place in the QS World University Rankings by Subject. In 2016 it was in 21st place in this annual ranking of leading universities in 46 disciplines.

An international partnership of brain researchers from 35 research centres - from the US to China - including the Leiden Institute for Brain and Cognition (LIBC), has collected resting-state functional MRI data from more than 1400 healthy volunteers and put the information online so that it is available…

Leiden University is among the top 100 universities in four prominent international rankings.

The University Libraries provide access to a wealth of information: from e-journals, e-books and databases to printed material. The libraries are more than just a gateway. As a service organization we also help researchers find information, manage their data, assess the best places to publish their…

When you apply for admission, you’ll be asked to submit several documents.

Your tuition fee depends on a number of factors, such as your nationality and your previous Dutch higher-education qualifications.

An overview of the research at the Cancer Dug Target Discovery group.

This project aims to identify which aspects of exploring a novel environment produce beneficial effects on memory. The effects of novelty will be investigated across the lifespan, including children, adolescents and older adults.

Research facilities within reach of LIBC members:

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Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…