504 search results for “pbpk modelling” in the Public website
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manifesto with five policy proposals for a post-COVID-19 development model
COVID-19 has shaken the world. 170 academics of eight different Dutch universities believe the time is right for a positive and meaningful vision. They signed a manifesto with a list of five policy proposals for a post-COVID 19 development model to cope with this pandemic and other social and environmental…
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Jan Willem Erisman on the nitrogen crisis: 'The measurement model works, but the minister is setting reduction targets that are too high'
Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…
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Laurens Smit awarded for best PhD student in Operations Research/Management Science
The New Jersey Chapter of the international Institute for Operations Research and the Management Sciences
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Noortje DannenbergScience
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Erik DanenScience
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Population Pharmacokinetic Modeling
Course
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Laboratories for Digital Archaeology
The Digital Archaeology research group manages two computer laboratories with different purposes: the teaching lab (F1.01) and the research lab (A1.13a).
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Mathematics-based strategies for repairing tumour blood vessels
How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?
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Population Pharmacokinetic Modeling
Course
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Modeling progress: event types, causal models, and the imperfective paradox
Lecture, Com(parative) Syn(tax) Series
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New technique to study vascular growth
Sonja Boas developed new techniques to study vascular growth computationally. The results of her research provide a better understanding into mechanisms behind vascular growth, which is relevant to the development of medical therapies. She defends her thesis 'Computational modeling of angiogenesis'…
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Computational User Modelling
Lecture
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Models and Explanation in Economics
Lecture
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Model painting with diverse techniques
Arts and leisure, Arts and leisure
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Advances in Frailty Models
PhD defence
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Rachel Schats joins Leiden Teachers Academy: ‘I am always trying to look for ways to make teaching stick better'
The Leiden Teachers Academy (LTA) was founded to help collaboration between excellent teachers. Osteoarchaeologist Dr Rachel Schats has been one of the latest additions to the Academy, nominated by the Faculty Board for the position as a Teaching Fellow. ‘In the LTA we talk about new innovations in…
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Impact of low-carbon electricity development on carbon emissions in China
Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Gibbs-non-Gibbs transitions and vector-valued integration
Promotor: W. T. F. den Hollander, F. H. J. Redig
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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The imperfect fuel cell model
Lecture, This Week's Discoveries
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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Expressive modelling with clay
Arts and leisure, Arts and leisure
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Dynamical Gibbs-non-Gibbs transitions and Brownian percolation
Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez
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Young Star Renske Donkers: how is she doing now?
How is Young Star Renske Donkers doing now? Early this year she was the second person ever to win the Young Star Award for the best bachelor student. After her bachelor Molecular Science & Technology, Renske is now busy with her master Chemical Process Engineering in Delft. ‘This award was a great boost…
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Modelling the lung in vitro
PhD defence
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Advancing Zebrafish Models in Proteomics
PhD defence
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How do you determine the right medicine dosage for a child?
What’s the right dosage of medication for children? Assistant professor Elke Krekels and her colleagues discovered that for some medicines, you can determine this quite simply. On 13 April Krekels received the TOP-Publication award during the annual spring meeting of the Dutch Society for Clinical Pharmacology…
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‘Investment risk is holding back energy transition’
The present market regulations make it extremely risky to invest in green energy, and this is impeding the fight against climate change. This is what Oscar Kraan writes in his dissertation. PhD defence on 25 April.
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Bayesian Inference for Gaussian Models
PhD defence
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Synthetic model microswimmers near walls
PhD defence
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Towards circular and energy-efficient management of building stock
Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.
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Virtual children help prevent withdrawal syndrome in real children
When children wean off from heavy medication, they often experience withdrawal symptoms. The severity of these symptoms is often difficult to predict. Pharmacologist Bas Goulooze developed a computer model to determine the best weaning strategy for each child. His research has now been published in…
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Computational Humanities: Models, Methods, and Tools
Lecture
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Interdisciplinary approach benefits brain research
How do practice and theory reinforce one another in neuroscience? Professor Birte Forstmann’s inaugural lecture on 2 October will be about building interdisciplinary bridges between cognitive neuroscience and cognitive models. Her approach may lead to brain research with fewer side-effects for patie…
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Learning and Unlearning from the Tunisian Model
Lecture, LUCIS Lecture
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Pottery: From Drawing to Digital 3D Model
Conference, Workshop
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Zebrafish as vertebrate model of Gaucher disease
PhD defence
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Abstract Behavioral Specification: unifying modeling and programming
PhD defence