... studies the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

With flexible learning pathways, students, supervised by their lecturer, have the flexibility to adapt their study career to suit their own individual goals.

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Promotores: J.C. van Houwelingen, S.A. van de Geer

High throughput microscopy

Pathways of toxicity

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

The Liverpool care pathway for the dying patient (LCP) is a multidisciplinary tool developed for the dying phase for use in palliative care settings. The literature reports divergent experiences with its application in a nursing home setting related to its implementation and staff competencies. The…

... which focuses on the development and use of new multivariate statistical tools needed for analyses of data collected in the four other programs.

With textnets it is possible to visualize and analyze textual data in novel ways.

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Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

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The main methodological aspects of the use of stepwise LCA estimators under different circumstances.

The research of our group is centered around dynamical systems, functional analysis and their interplay.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

Supervisor: Gerard van Westen

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

This thesis is based on five papers on several topics.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

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How does the cluster bootstrap procedure in combination with various types of linear models perform in the analysis of longitudinal data, compared to other methods.

Promotor: Prof.dr. E. Deprettere

Can we develop a platform for raw materials intelligence?

The master in Cultural Analysis: Literature and Theory at Leiden University focuses on the study of literature from a comparative and theoretical perspective, with a special emphasis on literary movements and genres of the 19th, 20th, and 21st centuries. It covers a wide range of languages and cultures…

What should the EU do to support Ukraine, Belarus and Moldova? How can the European Union adapt its policies towards these countries in a very difficult and challenging geopolitical context?

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

This project aims to improve understanding of, and responses to, the phenomenon of lone actors through analysis of comprehensive data on cases from across Europe.

Improvisers in experimental music do not record their music in a conventional score, but in ever-changing 'tactile pathways'. This is the proposition put forward by researcher Christopher Williams. PhD defence 13 December.

The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

There is little evidence of the routes connecting Amerindian communities in the Caribbean prior to and just after 1492. Uncovering possible canoe routes between these communities can help to explain the structure, capabilities, and limitations of the physical links in their social and material networks.…

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

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The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?