Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Research groups in the Quantum Matter & Optics programme investigate electronic properties of matter and light-matter interactions with emphasis on quantum information.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: Prof.dr. M.A.G.J. Orrit

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

This thesis discusses the discovery potential of Intensity Frontier experiments.

In this research, for the first time a detailed description as well as systematic and comparative analysis of the final particle system in Chinese are provided.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Duality, stochastic processes

Advancing the understanding of the interaction of light and matter on the single-quantum level is important for near-future quantum technologies but also to answer fundamental questions.

Our research primarily focuses on the early universe and its origins in theories that go beyond the Standard Model of particle physics.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…

A couple of years ago, theoretical physicist Carlo Beenakker tracked down the Majorana particles and inspired Leo Kouwenhoven from TU Delft to try to create them in a superconducting nano-structure. He succeeded in doing so in 2012, and the news made headlines around the world. But a lot of work still…

Promotor: W. Jiskoot, Co-promotor: A. Hawe

My work is motivated by the necessity to extend Standard Model of Particle Physics in order to explain three observed phenomena that this great theory fails to accommodate

The master’s specialisation Research in Physics, Quantum Matter and Optics at Leiden University offers a thorough experience on the front line of physics research with a practical training of communicative and computer skills. The programme focuses on Condensed Matter problems, such as Molecular Electronics,…

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

The research program of the QO group has three leading themes: Optical Physics, Quantum Optics, and Photon-Matter Interactions. We work mostly at the boundaries between these themes with entanglement as a bridging and binding agent.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.

Science, Leiden Institute of Physics (LION)

Science, Leiden Institute of Physics (LION)

Leiden physicists have created a light source that emits individual particles in an identical state through optical fibers. Using this setup, their measurements can last longer and are more efficient, meaning they can perform more in-depth research on bizarre quantum effects, such as interference and…

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

Research in the van Exter lab focuses on quantum aspects of light and light-matter interaction. One of our long-term goals is to develop a reliable quantum memory, based on a single emitter in an open micro cavity.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

This study explores regional variation in the use of utterance-final particles by analyzing spoken Taiwan Mandarin data recorded from spontaneous conversations.

The Western Mediterranean is a key region to understand human dispersal events within and out of the African continent as well as for the eventual replacement of Neanderthals by anatomically modern humans during the Pleistocene. Central to any conclusive interpretation of archaeological and palaeoclimatic…

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

At the center of this research project lies a practice-based, artistic exploration of the impact of digitalization on the lived reality of both physical and cognitive labor.

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.