2570 search results for “parkinson s disease” in the Public website
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Technique from new cars helps with surgery selection Parkinson's disease
When parking in reverse, your car skids off just a little, hitting the wall of the parking garage. On the car dashboard, a warning light immediately starts blinking. This technique from new cars can also be used for another purpose, namely in the treatment of Parkinson's disease patients.
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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Parkinson Protein α-Synuclein Binds Surprisingly Strong with Membrane
Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.
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Elizabeth (Liesbeth) de Lange
Science
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Milan Koch
Science
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New neuroimaging approaches in Parkinson's disease
PhD Defence
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Reversing cardiovascular diseases
How can the development of constrictions in the blood vessels be reversed?
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Clinical predictors of disease progression in Parkinson's disease
PhD Defence
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Veni Grant for Lucia Bossoni
Postdoc Lucia Bossoni has received an NWO Veni grant to research brain diseases for the next three years. She will work in labs at both the LUMC and the Leiden physics institute.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Magnetic Resonance Microimaging of Alzheimer's Disease
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Health and disease
Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Development & Disease in Microbial Sciences
Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.
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Development & Disease in Plant Sciences
Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
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metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Translational Summer School on Neuromuscular Diseases 2020
Due to the developments around the corona virus, the Translational Summer School on Neuromuscular Diseases is postponed to 2021.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Computer Science at Leiden University
Leiden Institute of Advanced Computer Science (LIACS)
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Novel chemical tools for target validation in neuroinflammation
In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?
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Kinetic profiling of positive allosteric modulators of the mGlu2 receptor
Supervisor: Maarten Doornbos
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Data-Driven Knowledge Discovery in Polycystic Kidney Disease
PhD Defence
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Lifestyle and nutrition to combat diseases (of affluence)
We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Predicting dementia
In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.