Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.

Two things are needed to produce fuel from sunlight: an antenna that harvests light, and a light-driven catalyst. The most efficient antennae contain bacteria. An international team headed by Huub de Groot imitated them and discovered how they function.

Photosynthesis is the origin of life on earth, but it is a phenomenon that is still barely understood. Take, for example, the extremely efficient mechanism of electron transport. Leiden researchers demonstrate for the first time where one particular cause of this might be found.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

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PhD Defence

Biophysicist Anjali Pandit has been awarded a FOM 'Projectruimte' research grant for her proposal ‘Tuning into the photosynthetic membrane with atomistic precision’.

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Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

Contact Biophysical Organic Chemistry/Solid State NMR

Research at the BPOC/SSNMR group is comprised of the following research themes:

We invite you to develop your academic skills by joining our research group and develop your own short term project in the bachelor phase. We offer longer term research projects for master students. 

A deceptively simple, complicated paper

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Due to the corona pandemic the 12th International Metabolomics Workshop has been postponed. The event will not take place from March 30 to April 17 2020. We will inform you via this website as soon as we have a new date.

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

PhD at Université de Picardie Jules Verne, Amiens - France

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands

Professor at the School of pharmaceutical sciences, University of Geneva - Switzerland

A full overview of BPOC/SSNMR PhD theses.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Metabolomics group, LCQUI, Universidade UENF, Campos dos Goytacazes/Rio de Janeiro - Brazil

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

The Basics and Applications to Plant Sciences HAS BEEN POSTPONED UNTIL FURTHER NOTICE.

Master projects are available in

Coordination chemistry is the chemistry of metal atoms "coordinated" by other atoms, ions or molecules. Important challenges in the research on coordination and organometallic chemistry are to understand the relation between the ligand and metal complex structures and the (catalytic) properties of the…

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

Dr. at the Department of organic chemistry, Wageningen University - the Nederlands

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Which plant leaf characteristics are involved in thrips resistance in tomato?

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle).

Promotor: H.J.M. de Groot

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

Which metabolites of sponge are influenced by individual environmental or biological factors?

Research projects

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

The Biological- and Soft-Matter Physics Master specialisation is one of the two programmes Leiden offers in experimental Physics. The programme can to a high degree be tailored to individual needs and interests.