The path to rational drug and dose selection

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Inaugural lecture

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

M. Danhof, Co-promotor: O.E. Della Pasqua

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

PhD defence

PhD defence

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Key publications of the Quantitative Clinical Pharmacology group

More attention should be paid to juvenile idiopathic arthritis. An early diagnosis and robust treatment can prevent irreversible damage. This is what paediatric rheumatologist Rebecca ten Cate said in her inaugural lecture on Friday 22 November 2019.

Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…

Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…

Marta Fiocco has been appointed as of 1 April as professor of applied mathematics, in particular medical statistics. Fiocco's appointment is at the Faculty of Science and at the Leiden University Medical Centre (LUMC). She conducts research into 'personalised medicine', tailor-made medicines for cancer…

‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…

Patients and healthcare providers use Remote Patient Management platforms to exchange information with each other. New methods like this are desperately needed to future-proof our healthcare systems. Professor Maaike Kleinsmann is working to scale up these systems and implement them nationwide.

Australian cell biologist Melissa Little and Dutch physicist Robbert Dijkgraaf will each be awarded an Honorary doctorate at the Dies Natalis of Leiden University in February 2019. They are receiving these awards for their services to science.

Doctors are entering the fray, court cases are being filed and smokers are becoming more of a pariah. From lobby expert to medical biologist: four Leiden researchers give their perspective on smoking, the tobacco industry and smoking policy

Patients who can’t afford medicine. Refugees who need help. Expats who are ill. All alongside research into obesity. Having trained as a doctor, Dennis Mook-Kanamori chose the hard reality of life as a GP together with a job as a researcher at the LUMC.

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