Successful completion of the procedure to obtain a doctorate culminates in the conferral of the academic degree of Doctor in a specific subject.

Smooth platinum electrodes roughen and wear when subjected to repeated cycles of oxidation and reduction, which causes nanometer-scale mounds to grow. Leiden chemists Leon Jacobse and Marc Koper, together with physicist Marcel Rost, discovered the exact details, using a unique tunneling microscope.

Imagine we could convert the greenhouse gas CO2 into synthetic fuels using sustainable energy. This would enable us to reduce the amount of CO2 and at the same time store wind and solar energy in an innovative way. Chemist Akansha Goyal (Leiden University) is conducting fundamental research to make…

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotor: R.D. Gill, F. Taroni

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Promotor: Prof.dr. M. Danhof

Promotor: T.H. Oosterkamp

The two-year Foundations of Computing programme (120 EC) includes mandatory core courses and electives, as well as a Master's Thesis Research Project.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Are there other planets like the earth, and will there also be life? Astronomers study planets around stars other than the sun, with the aim to find out what kind of gasses their atmospheres are made up with.

Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

In this thesis integral points on affine del Pezzo surfaces are studied.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

How does FoxP1 affect auditory perception on a behavioural and genomic level?

On 16 January 2020, Maaike Wensveen defended her thesis 'Eigen haard is goud waard?'. The doctoral research was supervised by Prof. P. Nieuwbeerta and Dr. J.M.H. Palmen.

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Middle Paleolithic stone tool technology is one of the major sources of information about Neandertal behavior and adaptations. The Balkan Middle Paleolithic often remains outside of the major debates and interpretations of Neandertal behavior.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

School of pharmaceutical sciences, University of Geneva - Switzerland

On 16 December 2021, Lisanne van Houten defended the thesis 'Flexing the Slot Regime'. The doctoral research was supervised by Prof. P. Mendes de Leon and Prof. L. Pierallini (Luiss University Of Rome).

On 20 January 2022, Marco Stam defended the thesis 'Essays on Welfare Benefits, Employment, and Crime'. The doctoral research was supervised by Prof. M.G. Knoef.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

Leiden LIS Budget Incidence Fiscal Redistribution Dataset on Relative Income Poverty Rates (2019), assembled by Koen Caminada and Jinxian Wang (Version 1, February 2019), presents the disentanglement of relative income poverty measurers and the anti-poverty effects of social transfers and income taxes…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

We would like to present to you a simple guidebook about living a sustainable life as a student in the cities of Leiden and The Hague. Whether you are a first-year student still trying to find your way around or already doing your masters – students wanting to explore more sustainable options and save…

The nanoscale structure of a catalyst under reaction conditions determines its activity, selectivity, and stability. For the production of sustainable energy and materials, new catalysts are needed. By understanding the structure-activity relationships of catalysts under reaction conditions, insight…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Lecture

Leiden based chemistry student and chess grandmaster proposes molecular system for development of artificial leaf

The European Project SUNRISE, ‘Solar energy for a circular economy’, has been selected as one of the six Coordination and Support Actions (CSA) within the Horizon 2020 programme of the European Commission. Funded with 1 million euros, it will set the base for a large scale European research project.…

Cars are equipped with catalysts to disarm toxic exhaust gases. Platinum plays an important role there. Leiden physicists and chemists have now for the first time seen the mechanism behind a platinum catalyst. With a fundamental understanding of the process, scientists can use this rare material more…

How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.

Leiden chemists Marc Koper and Ian McCrum have discovered that the degree to which a metal binds to the oxygen atom of water is decisive for how well the chemical conversion of water to molecular hydrogen takes place. This insight helps to develop better catalysts for the production of sustainable hydrogen,…

The E2CB programme has been launched to bring CO2 emissions to zero by 2050. The goal: to produce all raw materials for the chemical industry from sustainable sources. Professor of Electrochemistry Marc Koper is involved in the project.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.