Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Promotor: S.M. Verduyn Lunel

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

The book Uitdagend gedifferentieerd vakonderwijs bij Janssen, Hulshof and Van Veen describes a 'generative toolkit' for adapting education by teachers.

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

In this thesis three different topics in number theory are studied.

Promotor: H.W. Lenstra

A teacher perspective

Many teachers in secondary education take differences between pupils into account . PhD research by Saskia Stollman (ICLON) shows that they need room to experiment and the support of the school management

Promotor: R. Tijdeman

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Promotor: Prof.dr. F. den Hollander

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.

Three types of PLCs are studied, varying on the dimension of autonomy of and interdependency between teachers: Joint work, Aid and assistance and Shared practices.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

On 12 April 2022 Alok Oak successfully defended a doctoral thesis and graduated.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

How do teachers’ knowledge, practices, perceptions, job satisfaction and workload in secondary education develop during a school innovation in the context of differentiated student development?

In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

This project aims to analyze and increase student motivation and achievement during the first three years of secondary school with an intervention that focuses on development of students’ talents.

Research has shown that the impact of feedback can be very powerful on second language acquisition. However, how to provide adaptive feedback on speaking skills in foreign languages and how to provide differentiated support in secondary schools in regular secondary schools classes of often 25-30 students?…

Science, Leiden Academic Centre for Drug Research (LACDR)

In this thesis we study bistable reaction-diffusion equations on lattice domains.

Mr. Ade Jaya Suryani defended his thesis on 28 January 2021

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

Many teachers in secondary education take differences between pupils into account . PhD research by Saskia Stollman (ICLON) shows that they need room to experiment and the support of the school management. Defence on May 23, 2018.

In this dissertation, a corpus of 595 seventeenth-century letters (mainly private ones) written between 1664 and 1672 is examined from a sociolinguistic perspective.

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

What relationships exist between different types of PLCs and cognitive differentiated teaching?

Promotor: Roeland M.H. Merks

Science, Leiden Academic Centre for Drug Research (LACDR)

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Existing work in probabilistic language modeling can be mostly divided into two categories:

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

As of 1 September, Marco van Eijk has been appointed Director of Education of the bachelor's programme Life Science & Technology. He succeeds Marcellus Ubbink, who moved to the position of Scientific Director of the Leiden Institute for Chemical Research (LIC). Van Eijk has been appointed for a period…

Plants that grow in patterns of stripes on the edge of deserts, plankton that live on the sea bed or oscillate in the water, and melanomas that spread throughout the body. Mathematician Lotte Sewalt discovered the common elements in these three systems. PhD defence 8 September.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. E. Deprettere

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.