The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

Pathways of toxicity

Over the past decade, several novel types of spatially resolved

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

PhD Defence

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

PhD Defence

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

Lecture

The division of Systems Biomedicine and Pharmacology focusses on personalised medicine and the development of novel systems-based approaches in translational and clinical pharmacology.

PhD Defence

The Faculty of Medicine

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

PhD Defence

PhD Defence

PhD Defence

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Dr. at Agriculture and AgriFood Canada, Ottawa Research & Development Center - Canada

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

The Faculty of Science

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…

The Basics and Applications to Plant Sciences will be held physical. See below for more information.

Key publications of the Quantitative Pharmacology group

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.

Science, Leiden Academic Centre for Drug Research (LACDR)

Science, Institute of Biology Leiden (IBL)

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Physics and Engineering Approaches to Biomedicine and Pharmacology

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

An overview of the research at the Cancer Dug Target Discovery group.