Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

A deceptively simple, complicated paper

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

In this thesis, we present new laboratory data of interstellar dust analogues.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

Paramagnetism. An obscure occult practice? No. It’s one of the newest scientific methods for mapping the behaviour of proteins with great precision. Marcellus Ubbink has been awarded 3 million euro by NWO and Leiden University to purchase a very powerful instrument. The goal: to acquire greater insight…

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Various ministries started building nuclear bunkers in the seventies to shield themselves from a possible nuclear attack from the East. One of these nuclear bunkers lies below our new Wijnhaven building. This specific bunker was designed for important figures of government, and was built to function…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

On NPO radio programme 1op1 about nuclear weapons negotiations, Jaap de Hoop Scheffer, Professor of International Relations and Diplomatic Affairs at the Institute of Security and Global Affairs, says that ‘all nuclear treaties must be scrutinised afresh.’

This thesis presents the anharmonic infrared spectra of a series of polycyclic aromatic hydrocarbons. Comparisons and characterizations are made based on high-resolution low-temperature gas-phase experimental spectra.

First author Rubin Dasgupta, PhD student at the Biophysical Organic Chemistry & Macromolecular Biochemistry groups at the Leiden Institute of Chemistry has made the cover of the June edition of Solid State Nuclear Magnetic Resonance.

With the opening of Wijnhaven, Leiden University now has three locations in The Hague. Photographer Nicole Romijn recorded the construction process of the former ministry building from start to finish. The result can be viewed at the photo exhibition on the Wijnhaven Building in the Old University Library…

A lot of our research is performed at temperatures close to absolute zero, among other reasons because this increases the sensitivity of the measurements. 

It is partly thanks to Leiden professor Michel Orrit that we are today able to study individual molecules. He just missed winning a Nobel Prize, but is today the recipient of another important scientific award: NWO’s prestigious Spinoza Prize.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

On Tuesday 16 April, the Institute of Security and Global Affairs (ISGA) of Leiden University and the Advisory Council on International Affairs (AIV) organised a panel discussion on the recommendations of the report: ‘Nuclear weapons in a new geopolitical reality’. In this report the AIV recommends…

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

You can still enroll for the master Magnetic Resonance Physics course. It starts at Monday, Nov. 13th 13:30 in HL 226. For more information go to https://studiegids.leidenuniv.nl/courses/show/76629/magnetic-resonance-physics

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

PhD Defence

PhD Defence

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

The National Roadmap for Large-Scale Research Facilities programme of NWO enables the building or renovation of research facilities with international allure. Leiden NMR groups take part in the uNMR-NL consortium coordinated by Marc Baldus (Utrecht University) that has been awarded almost 18 million…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Conference

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?