154 search results for “nmr” in the Public website
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Dynamics of a β-lactamase
BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.
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ParaNMR Facility
The Paramagnetic NMR Facility Leiden has been established to provide support to researchers who want to apply paramagnetic NMR spectroscopy to biomolecules. Support is offered in the design and synthesis of paramagnetic probes, either for general application (such as lanthanide tags and spin labels)…
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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MRI Machine at the Nanoscale Breaks World Records
A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.
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Unveiling the invisible conformational landscape of cytochrome P450
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A metabolomics resistance test
Can metabolomic profiling be used to predict resistance against insect herbivores in plants?
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Biophysical Organic Chemistry
The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…
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PhD Theses
A full overview of BPOC/SSNMR PhD theses.
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PhD candidate
Science, Leiden Institute of Chemistry (LIC)
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Anthe Janssen receives Unilever Research Prize 2014
Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.
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First step in converting solar energy using ‘artificial leaf’
Two things are needed to produce fuel from sunlight: an antenna that harvests light, and a light-driven catalyst. The most efficient antennae contain bacteria. An international team headed by Huub de Groot imitated them and discovered how they function.
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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The ecological relevance of chemical diversity in plants: pyrrolizidine alkaloids in Jacobaea species
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Magnetic Resonance Imaging of the Adult Zebrafish
Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…
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Weak coupling between magnetically inequivalent spins: the deceptively simple, complicated spectrum of a 13C-labeled trimethyl amine
A deceptively simple, complicated paper
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Photosynthesis works with valves
Photosynthesis is the origin of life on earth, but it is a phenomenon that is still barely understood. Take, for example, the extremely efficient mechanism of electron transport. Leiden researchers demonstrate for the first time where one particular cause of this might be found.
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applications of paramagnetic NMR spectroscopy for protein research
PhD Defence
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Deciphering the complex paramagnetic NMR spectra of small laccase
PhD Defence
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Student projects
We invite you to develop your academic skills by joining our research group and develop your own short term project in the bachelor phase. We offer longer term research projects for master students.
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Crystal Cave
X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.
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Membrane Interactions
Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Metabolic Characterization of Marine Sponge
Which metabolites of sponge are influenced by individual environmental or biological factors?
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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Jean-Luc Wolfender
Professor at the School of pharmaceutical sciences, University of Geneva - Switzerland
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Expertise
The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.
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Hye Kyong Kim
PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands
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Research Grant for tuning into photosynthesis
Biophysicist Anjali Pandit has been awarded a FOM 'Projectruimte' research grant for her proposal ‘Tuning into the photosynthetic membrane with atomistic precision’.
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Mechanism MRI amplifying agents explored
Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…
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Natural Products Lab
We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.
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A semisynthetic peptide-metalloporphyrin responsive matrix for artificial photosynthesis
This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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Terpenoids and terpenoid indole alkaloids in Catharanthus roseus cell suspension cultures
Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte
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Jan Schripsema
Metabolomics group, LCQUI, Universidade UENF, Campos dos Goytacazes/Rio de Janeiro - Brazil
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Polyfluorinated bis-styrylbenzenes as amyloid-beta plaque binding ligands
Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.
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Identification of productive and futile encounters in an electron transfer protein complex
PNAS publication on protein encounter complexes
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In vitro and in vivo evaluation of synergistic and opposing effects of Chinese herbal medicine and natural compounds on immuno-modulation.
Can we link multiple components from herbal extracts with their biological activities?
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Projects
Research projects
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Teris van Beek
Dr. at the Department of organic chemistry, Wageningen University - the Nederlands
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In vitro investigation of the photoprotection mechanism of Light Harvesting Complex II
Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle).
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
PhD Defence
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Fundamental Research in Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Postdoc Unlocking Nature’s Pharmacy from Bogland Species
Science, Institute of Biology Leiden (IBL)
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14th International Metabolomics Workshop
The Basics and Applications to Plant Sciences will be held physical. See below for more information.
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines