BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The Paramagnetic NMR Facility Leiden has been established to provide support to researchers who want to apply paramagnetic NMR spectroscopy to biomolecules. Support is offered in the design and synthesis of paramagnetic probes, either for general application (such as lanthanide tags and spin labels)…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.

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Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

A full overview of BPOC/SSNMR PhD theses.

Science, Leiden Institute of Chemistry (LIC)

Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.

Two things are needed to produce fuel from sunlight: an antenna that harvests light, and a light-driven catalyst. The most efficient antennae contain bacteria. An international team headed by Huub de Groot imitated them and discovered how they function.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

A deceptively simple, complicated paper

Photosynthesis is the origin of life on earth, but it is a phenomenon that is still barely understood. Take, for example, the extremely efficient mechanism of electron transport. Leiden researchers demonstrate for the first time where one particular cause of this might be found.

PhD Defence

PhD Defence

We invite you to develop your academic skills by joining our research group and develop your own short term project in the bachelor phase. We offer longer term research projects for master students. 

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

Promotor: H.J.M. de Groot

Which metabolites of sponge are influenced by individual environmental or biological factors?

How does the photoregulation mechanism work in detail?

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

Professor at the School of pharmaceutical sciences, University of Geneva - Switzerland

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands

Biophysicist Anjali Pandit has been awarded a FOM 'Projectruimte' research grant for her proposal ‘Tuning into the photosynthetic membrane with atomistic precision’.

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Can new variants of daptomycin and the polymyxins be found?

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Metabolomics group, LCQUI, Universidade UENF, Campos dos Goytacazes/Rio de Janeiro - Brazil

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

PNAS publication on protein encounter complexes

Can we link multiple components from herbal extracts with their biological activities?

Research projects

Dr. at the Department of organic chemistry, Wageningen University - the Nederlands

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle).

PhD Defence

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Science, Institute of Biology Leiden (IBL)

The Basics and Applications to Plant Sciences will be held physical. See below for more information.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Development of Natural Resource for New Medicines