In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

There is no heritage without emotional sharing and clashing. This article explores the involvement of divergent emotions in heritage making by discussing the debate series of Imagine IC and the Reinwardt Academy and zooming in on the commemoration of slavery and imagery of ‘Black Pete’ in the Netherlands.…

Renate Dekker defended her thesis on 7 November 2017.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

If you would want to set up an alumni network after you graduated in Leiden and returned to your home country, how would you go about it? Seven Leiden alumni in China did not hesitate and decided to just do it! Last year they launched the Leiden Alumni Chapter in China, an initiative which was met with…

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

Beyond Empires explores the complexity of empire building from the point of view of self-organized networks, rather than from the point of view of the central state.

Sasha Goldstein defended her thesis on 10 January 2019

This thesis describes a study from both a theoreticaL and an experimental point of view.

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

The principle aim of the project is to study the genesis and the quantitative properties of the Early Roman urban network of the Balkan and the Danube provinces.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

PhD Defence

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

Promotor: J. A. Bouwstra

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Jifeng Liu defended his thesis on 2 February 2017

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

Book by Soledad Valdivia Rivera

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Since the emergence of humankind people have maintained social contacts and traveled widely, establishing interaction networks in which goods are traded and ideas are transmitted, increasingly on a global scale.

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Professor Frank den Hollander has been awarded a 10-year grant through the NWO Gravitation program, jointly with colleagues from the University of Amsterdam, the Center for Mathematics and Computer Science in Amsterdam, and the Technical University of Eindhoven.

Conference

Lecture

The group structure of Jihadist networks changes rapidly, which makes it difficult to monitor them. This is the finding of research by criminologist Jasper de Bie. PhD defence 14 April.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

The modern-day Caribbean is a stunningly diverse but also intricately interconnected geo-cultural region, resulting partly from the islands’ shared colonial histories and an increasingly globalizing economy.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

To address the relevance of Christianity to the ideological negotiations with the officially established authority, this research will be conducted by asking how the history enthusiasts negotiate the Christianity-related ideology through reconstructing the Christian past and reproducing religious histories…

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

‘It has never been so easy to set up a Studium Generale series.’ With these words Tilman Grünewald thanked speaker Frank den Hollander, who kicked off the Studium Generale series on complex networks on Monday 20 February.

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

Mechanical interactions between cells and their environment play an important role in many biological processes.

In 2018 NETWORKS organised a very succesful masterclass on networks and their applications for secondary school students with the title 'NETWORKS goes to school'. This week, NETWORKS published the collection of contributions with an extensive introduction. The aim of both the masterclass and this…