Beginning teachers often experience difficulties making activating lessons. This study investigates how and if the practical teaching model can offer them a hand in learning to design lessons.

Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations

Recent concerns about cultural identity emphasise the ongoing political and social importance of the question of how, and with whom, people identify. Changing and conflicting identities were highly relevant for pre-modern Europe. Paradoxically, the more powerful states became, the more their rulers…

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Which adolescents are more at risk of developing social anxiety disorder later in life?

This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

M. Danhof, Co-promotor: O.E. Della Pasqua

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Read more about the International Network Open Science & Scholarship Communities in our Vision and Mission statements.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Behrouz Karoubi defended his thesis on 15 June 2016

The current study focuses on Walpole’s social network and the language as contained in the letters of the network members.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?

This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Promotores: Prof.dr. G.R. de Snoo & Dr. R. Heijungs

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Science, Institute of Environmental Sciences (CML)

NETWORKS, a new consortium of 11 researchers from the University of Amsterdam, Technical University Eindhoven, Leiden University and CWI aims to address the pressing challenges posed by large-scale networks using stochastics and algorithms.

Medieval and early modern Europe was a world of constantly shifting borders, strong local political traditions, profitable transnational trade, and dense networks of international relations. In this world, ‘identity’ was never monolithic.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Promotor: Prof.dr. M.K. Richardson

Promotores: H. Schiessel, G.T. Barkema

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Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

Lecture, Sociolinguistics Series

How can we culture an artificial vascular network to support tissue development ex vivo?

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

"Visualizing Cryptographic Networks" will enhance the completion of a monograph with the design of an open access web-laboratory.

Mr. Sujadi defended his thesis on 29 June 2017

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

The central aims of this project are to establish the shapes of the various urban hierarchies existing in the provinces of the Roman Empire and (especially) to use the quantitative properties of these hierarchies to shed new light on levels of economic integration.