16 search results for “neonates” in the Public website
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Pharmacodynamics of analgesics and sedatives in neonates and infants
In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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and pharmacodynamics of routinely used off-label drugs in premature neonates
Currently, more than 80% of drugs are used in an off-label manner in critically ill neonates.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Neonatal screening with pulse oximetry
PhD Defence
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Research
Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…
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Quantitative Clinical Pharmacology
The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…
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Fetal and Neonatal Alloimmune Thrombocytopenia evidence based screening
PhD Defence
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Neonatal brachial plexus palsy Impact throughout the lifespan
PhD Defence
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Neonatal hematological and biochemical complications in TTTS and TAPS
PhD Defence
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Key publications
Key publications of the Quantitative Clinical Pharmacology group
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Fetal and Neonatal Alloimmune Thrombocytopenia: towards implementation of screening in pregnancy
PhD Defence
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Winning the 2016 Pharmaceutical Research Meritorious Manuscript Award
The publication by the group of Catherijne Knibbe was awarded the 2016 AAPS Pharmaceutical Research Meritorious Manuscript Award.
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compliance in oxygen saturation targeting in preterm infants in the neonatal intensive care unit
PhD Defence