Operators in the Lexicon opens with an old chestnut: why are there no natural single word lexicalizations for negations of the propositional operator and and the predicate calculus operator all: why neither *nand nor *nall?

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

-

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Cutting down global emissions of greenhouse gases to combat global warming won’t do the trick alone: we also need negative-emissions technology that can capture carbon dioxide directly out of the air. In the prestigious journal Global Environmental Change, PhD candidate Oscar Rueda and colleagues shed…

Social assistance and minimum income benefits are important instruments as a safeguard against low income and poverty. There have been major developments in minimum income benefits both in developed and developing countries over the last decades. Our study collects several empirical studies regarding…

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

To study relationships between emotion regulation after negative and traumatic life events and psychopathology. Within this context, another goal is to develop and validate emotion regulation questionnaires.

Petra van der Bekerom, Joris van der Voet, and Johan Christensen, three assistant professors at Leiden University, conducted a large-scale survey experiment about whether citizens are more negative about failing service delivery than private organizations.

Lecture

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

‘It's right and proper that we have policies to prevent terrorism,' says Francesco Ragazzi, university lecturer in International Relations at Leiden's Institute of Political Science. 'But the way the policies are designed and implemented can have unintended consequences. For example, when teachers are…

Negative perceptions of ambiguous social cues, social performance and physical arousal in socially anxious youth

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Are traces of fire use detectable in ancient hominin genomes?

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

This book reveals how one publishing firm's editorial strategy helped to legitimate European colonialism in the early modern era.

A selection of recent publications from the Plant BioDynamics Laboratory.

This dissertation provides an account of polar questions in Italian dialects from a typological, theoretical and empirical perspective.

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

On 29 June 2017, Doris Dull-Zessner defended her PhD dissertation “Value Congruence in a Multinational Corporation”. The supervisors are Professor J.A.A. Adriaanse and Professor J.I. van der Rest.

Promotor: Prof.dr. D. Bouwmeester, Co-promotor: M.P. van Exter

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

PhD Defence

PhD Defence

Promotor: Prof.dr. C.U. Keller, Co-promotor: Dr. ir. Frans Snik

Heritage Quest has featured in several media. Read and watch the items made by others about the project.