How distance-dependent is graphene as biological sensor?

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: T. H. Oosterkamp

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Can we build a biosensor to detect neuroblastoma markers in urine using the chemotaxis system in E. coli?

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

Leiden and Jülich researchers discovered an elegant and simple approach to improve the sensitivity of graphene biosensors. These so-called ‘next generation graphene electronic biochemical sensor devices’ are able to detect very low amounts of HIV DNA thanks to their very low electronic noise.

What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

From filtering UV light in sun cream to preventing perspiration odour in socks and sterilising fridges and washing machines. The use of nanoparticles in products is increasing. But what is the impact of these miniscule particles on the environment?

Free playtime and physical play are of great importance to children's social development. That is the main conclusion of innovative research by developmental psychologists and computer scientists from Leiden University.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Individual molecules are extremely hard to see through feeble fluorescence. Tiny gold nanorods serve as new antennas to intensify their signal 500 times. Publication on 24 February in Angewandte Chemie.

'Quality Nano' funded research of the Institute of Environmental Sciences to work in Exeter University for 20 working days, which allows the institute to access highly advanced equipment needed for evaluation the toxicity of nanoparticles.

As fruit and vegetables ripen, ethylene gas is released. Ethylene also influences the speed at which they ripen. Chemist Tom van Dijkman studied how small and inexpensive sensors can be made that measure ethylene concentrations during transportation. PhD defence 12 May 2016.

Plants use sunlight to perform photosynthesis, but with too much light they have to dim their activity and protect their cells against photo damage. The protein PsbS acts as a light-stress sensor and plays a key role in this process. Article in Nature’s Scientific Reports.

Leiden physicists and international colleagues from Geneva and Barcelona have confirmed the mechanism that makes magic-angle graphene superconducting. This is a key step in elucidating high-temperature superconductivity, a decades-old mystery central to physics, which may lead to technological break…

Coordination chemistry is the chemistry of metal atoms

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

PhD Defence

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

Machine Learning is becoming a more and more substantial technology for industry.

The change from a closed institution to an open living environment for patients with late stages of dementia will give the patients more freedom in their day-to-day life. The effect of this change on the patients’ mobility, activity and interaction with others will be assessed with sensor technology…

PhD Defence

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With his ice-cold nano force sensor, Tjerk Oosterkamp searches for the boundary between the quantum world and the everyday world. The Leiden physicist has received an NWO subsidy of 600,000 euros.

Former PhD, Bachelor and Master students of the Van Exter Lab

PhD Defence

Researchers of the Leiden Institute of Advanced Computer Science (LIACS) have started a 4 year project on developing a system that sends out automatic alerts when components from engines are showing first signs of fatigue.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Schneider

PhD Defence

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…