The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

In the first part of this thesis we study the geometry of folding patterns.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

The members of LUXs develop and validate new methods and algorithms for analysing data, and apply these in a wide range of problems. Their research ranges from multidisciplinary applications to proving mathematical theorems.

Next April, Leiden will host the seventh annual international Survival Analysis for Junior Researchers conference (SAfJR2018). This three-day event is aimed at career-young statisticians with an interest in the application and development of time-to-event analysis and related topics. The conference…

PhD student Robbin Bastiaansen applies mathematics to get insight in practical problems. By comparing mathematical models with developments in existing ecosystems, he hopes to demystify the process of desertification. His research has been published in Proceedings of the National Academy of Sciences…

We have to do all we can to stop climate change. But: the Earth is more resilient than we thought. That is the surprising conclusion of an international team of ecologists and mathematicians, which included Leiden mathematician Arjen Doelman. The team discovered that ecosystems can still avoid tipping…

Survival Analysis for Junior Researchers 2018 was hosted in Leiden.

Conference

Lecture

Below thesis archives will be moved shortly (work in progress) to the Leiden Repository. Once this is done, theses submitted by MI students (from 2008 onwards) can be accessed via the Repository and will be removed from this site.