577 search results for “mouse models” in the Public website
-
Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
-
Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
-
Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
-
Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
-
PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
-
Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
-
Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
-
Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
-
Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
-
Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
-
Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
-
Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
-
Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
-
Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
-
Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
PhD defence
-
Drug research
In the theme Drug research we generally work with rodents.
-
Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?
-
Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
-
Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
-
Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
PhD defence
-
Minimal structure modeling
Existing work in probabilistic language modeling can be mostly divided into two categories:
-
Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
-
Systems Modelling Lab (SML)
Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.
-
Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
-
Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
-
Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
-
Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
-
Animal models for cutaneous vaccine delivery
Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.
-
In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska
-
Model painting with diverse techniques
Arts and leisure, Arts and leisure
-
Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
-
Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
-
Self-regulation models
... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.
-
Data Driven Modeling & Optimization of Industrial Processes
Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.
-
Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
-
Expressive modelling with clay
Arts and leisure, Arts and leisure
-
Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
-
Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
-
Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
-
Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
-
Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.
-
Development of a Dynamic Substance Stock Model
Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.
-
Statistics when your models are wrong
Peter Grunwald
-
Advanced in vitro models for studying drug induced toxicity
Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price
-
Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
-
Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
-
Case studies in archaeological predictive modelling
ASLU 14
-
Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
-
Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
-
On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.