How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Promotor: Prof.dr. J. den Hertog

Source: Mediators Inflamm (2014)

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Molecular Physiology is a research group at the Leiden Institute of Chemistry, headed by Prof. Mario van der Stelt. The research aim is to design, synthesize and apply new chemical tools to answer important biological and medical questions. We use activity-based protein profiling, assay development,…

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

Chemistry is all around us: from nutrition and smartphones to medicine. The field is developing rapidly, as the world population continues to grow and resources become scarce. MST will educate you on the basics of working towards a clean and healthy world.

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Mechanical interactions between cells and their environment play an important role in many biological processes.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Mechanisms fro drug resistance

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

In what ways can a photographic practice act as a means to confront, or even undo, the various material properties of atmospheric enclosure that so clearly put our relationship with our environment under pressure? Is it possible to devise a set of critical and artistic strategies to comprehend the ways…

Bouwmeester

What is the Fine Mechanical Department?

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

PhD Defence

Promotor: Prof.dr. G.J. Kroes

PhD Defence

PhD Defence

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram

How can the transport of molecules in living cells help to target medicines at exactly the right place?