The overall aim of the project is to investigate effective ways to strengthen vocational identity of at-risk adolescents in order to contribute to a successful transition from late secondary to post secondary lower vocational education or to work.

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

Science, Leiden Institute of Advanced Computer Science (LIACS)

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Cardiovascular diseases are still a major concern for the global health.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

Promotor: J. A. Bouwstra

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

What are the conditions under which coercive diplomacy can compel a State to abandon its controversial nuclear (weapons) program? Based on the experience of the US coercive diplomacy against the nuclear programs of three countries, namely Iran, Libya and South Africa, Jean Yves Ndzana’s PhD research…

We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.

Programming is an excellent career option for blind children, and a way to have fun and express themselves. But the existing tools for programming are often not suitable for the blind and visually impaired. Leiden researchers will change that.

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

The Medieval Academy of America (MAA) is excited to announce the launch of a new Summer Research Program for early PhD or early PhD-track students. The 2022 Summer Research Program will convene over Zoom, over the course of six weeks in July and August. The Summer Research Program will culminate with…

On Saturday, 23 October 2010, the Benelux Algorithm Programming Contest (BAPC) was held in Leiden. In Studentcenter Plexus, 20 teams of students from colleges and universities in the Benelux competed for prizes up to EUR 1024,-. They were given 10 algorithmic programming problems, from which they had…

The Leiden team

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

Students of Mathematics and Computer Sciences Josse van Dobben de Bruyn, Mathijs van Nes and Bas Nieuwenhuizen will represent Leiden University in the World Finals Programming 2013 in St. Petersburg. From 30 June to 4 July, the 240 smartest programmers from universities around the world will come together…

The easy-to-learn programming language Hedy has been used more than 100,000 times in no more than 9 months. Felienne Hermans was a guest in the broadcast of the radio program Science071 to tell more about it.

‘We are surrounded by software and thus it is important that every child learns to program,’ says Felienne Hermans, associate professor at the Leiden Institute for Advanced Computer Science (LIACS). Hermans won the Dutch Prize for ICT Research 2021 in January, after which NRC interviewed her about her…

What languages do you speak? According to Felienne Hermans, ‘Python’ could be an answer to this question. Hermans studies how people learn to program at the Leiden Institute of Advanced Computer Science (LIACS) of Leiden University. In an article of the NewScientist she explains why programming is similar…

Does a universal psychoeducational course about stress in adolescents: I) lead to an increase in knowledge of stress?, II) affect the frequency with which stressors are experienced and the overall stress level?, III) create interest in a tier 2 level follow-up training?, and IV) appeal to students in…

The Benelux Algorithm Programming Contest 2010 (one of the qualifying rounds of the ACM International Collegiate Programming Contest) will take place on Saturday 23 October in Plexus, Leiden. This programming contest is organizedby De Leidsche Flesch (study association of ComputerScience/Mathematics/Physics/Astronomy…

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

The Central European University is a graduate-level, English-language university with a multi-disciplinary Medieval Department that offers MA and PhD programs in Late Antique, Medieval and Early Modern Studies as well as in Cultural Heritage Studies. Deadline: 1 February 2023.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

The five-year DIGITAL TWIN program can start as NWO granted 4 million euros from the Perspective program. With this grant, 19 new researchers will be appointed.

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

The connection between programming and reading seems non-existing. Yet in the new reading book ‘De Programmeerbende’ they go together very well. On 26 February author Inge Strijker and co-inventor and computer scientist Felienne Hermans launched the book at the Leiden Institute of Advanced Computer…