We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

We see computer programming as an essential skill. It enables you to be self-sufficient in building tools, processing data, visualizing research output, communicating research results, etc. Moreover, it empowers you to make beautiful things.

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

When deciding whether a Master's program is right for you, it is important to always compare other programs. Find out which one best fits you.

Promotor: Roeland M.H. Merks

The Leiden University Centre for Professional Learning has acquired the exclusive license in Europe 2018 from the American Certified Public Manager® Program. This program is carried out in cooperation with partners in Europe. The language of instruction of this program is English.

Are you eager to bring your own questions and curiosity into scientific research? Do the creation of media and use of technology drive your research interests? Could you be a researcher who challenges scientific practice and pushes its boundaries?

Promotor: F. Arbab

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Existing work in probabilistic language modeling can be mostly divided into two categories:

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Here you can find an overview of the offered courses provided by the Department of Economics per study program.

Promotor: Prof.dr. E. Deprettere

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Many countries and regions face a wide variety of challenges resulting from migration and mobility. Solutions that have been formulated range from policies and regulations for immigration, to education and stimulating social participation, to restructuring the welfare state. These challenges and policies…

Arts and leisure, Arts and leisure

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Taking the changing landscape of international cyber security and cyber conflict as a point of departure, The Hague Program on International Cyber Security focuses on the various modes of governance that states and other actors can bring into play to deal with and shape the strategic changes and challenges…

The Leiden Certified Public Manager® Program comprises 300 hours of structured learning (blended input, applied learning and joint inquiry) and runs over twelve months and starts in Autumn 2017. Academic and practitioner faculty members organise, coordinate and teach the programme. The Leiden Certified…

A research program that focuses on the development and implementation of cyber norms.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

The basic program comprises a total of thirteen courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular). The courses have…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

Peter Grunwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

ASLU 14

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.