Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Natural resources are becoming increasingly scarce. If we want to maintain our current standard of living, we will need inventive solutions. The researchers at the Institute of Environmental Sciences (CML) share their thoughts on how to achieve a fully circular economy in which as little use as possible…

CML is an institute of the Faculty of Science of Leiden University.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Social and Behavioural Sciences, Political Science

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Promotores: Prof.dr. G.R. de Snoo & Dr. R. Heijungs

Does knowledge of environmental performance change farmer's behaviour?

Science, Institute of Environmental Sciences (CML)

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

How to ensure the environmental and economic benefits of circularity transition at macro-scale?

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Using the principles of Industrial Ecology in Environmental Policy making in two cases: transition to a hydrogen economy and chlorinated compounds.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

The project’s overall goal is to improve Indonesia’s environmental legal framework and its implementation by strengthening the regulatory capacity of the government, and by enhancing the capacity of CSOs and scholars to hold the government accountable for its regulatory performance.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: W.T. de Groot

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Science, Institute of Environmental Sciences (CML)

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

They were called 'annoying brats', the group of campaigning scientists who in 1978 founded what is now an internationally acclaimed ecological research institute. Their stories and those of the current staff of the Institute of Environmental Sciences are described in the book 'Forty years of Leiden…

Evaluating the environmental consequences of diet changes in the European Union.

Various departments of the university have worked on developing the institution’s environmental policy plan: het Milieubeleidsplan Universiteit Leiden 2016-2020.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

The world abounds with different footprints that calculate human impact on the environment. Environmental specialist Kai Fang is the first person to have developed a family of footprints that allow better measurement of environmental damage and the depletion of natural sources. PhD defence on 24 Nov…

Promotor: Prof.dr. E. Deprettere

Corporate environmental offending as a source of conflict: Prevention through perceived legitimacy?

An effective and equitable approach to resource conflicts?

In the absence of stringent and coordinated international action, States might seek alternatives to promote environmental protection unilaterally.