Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

It is a known trait in humans to anchor innovations in the past, so as to make new developments easier to accept. It is an aspect of humanity that can also be spotted in classical and prehistoric times. Archaeologist Daniel Turner will investigate the anchoring of monumental building in Greek Prehistory…

How is Young Star Renske Donkers doing now? Early this year she was the second person ever to win the Young Star Award for the best bachelor student. After her bachelor Molecular Science & Technology, Renske is now busy with her master Chemical Process Engineering in Delft. ‘This award was a great boost…

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Samineh Bagheri is our Leiden Institute of Advanced Computer Science’s nominee for the C.J. Kok Jury Award 2020.

Mechanical interactions between cells and their environment play an important role in many biological processes.

Promotor: M.L. van Hecke, Co-Promotor: B.P. Tighe

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

We simulate interstellar clouds with special plasma expansions and chemical reactions on icy dust grains to be measured in ultra-high vacuum setups. This provides the data necessary to guide and interpret astronomical observations and to model reaction networks in space. [Harold Linnartz]

Promotor: Prof.dr. J. Zaanen, A. Parnachev

Dave R. Stikkolorum, Michel R.V. Chaudron, Oswald de Bruin won the Best Paper Award of the Model Gamification Contest at the ACM/IEEE Models 2012 Conference for their paper: The Art Of Software Design, a Video Game for Learning Design Principles.

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Course

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Cosmologists have many possible models for the Universe, of which only one can be true. A new flowchart will eliminate some of them when two specific Universe features are accurately measured. Publication in Physical Review D on 7 November.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

Dive into the heart of archaeological science: explore the flora and fauna of bygone ages, study human bones and teeth, analyse the cultural biographies of material objects, or become an expert in the use of digital data in archaeological research.

Course

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

The main methodological aspects of the use of stepwise LCA estimators under different circumstances.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Cardiovascular disease is the leading cause of death worldwide.

Experts from several disciplines have raised concerns about the use of seemingly precise models to guide policies in matters as complex as the current Covid-19 pandemic. 22 scholars wrote down five principles on how to responsibly use scientific models. This comment was published in Nature on 24 June…

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

A full overview of all loans and debts between banks would help preventing a new financial collapse. But banks do not provide this information. An econophysics model by Diego Garlaschelli and collaborators reconstructs the most probable situation and finishes first place in two independent tests.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

How do processes of coalition-formation influence patterns of decision-making in the European Union?

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

The precolonial inhabitants of the Caribbean islands communicated, travelled, and exchanged objects and ideas along an expansive inter-island network. New methods of computer modeling shed light on these networks. Emma Slayton is set to discuss her work on this topic at her Defense on the 12th of Se…

Promotor: A.P.IJzerman Co-promotor: A. Bender

Linking Empirical Academic thinking with Legal Practice. Internationally and particularly in the Netherlands. By René Orij, April, 2016.