Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: Prof.dr. J. Memelink

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Promotor: J.M. Memelink

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Can epigenetic changes explain associations between early life stress and health outcomes?

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

A deceptively simple, complicated paper

Promotor: Prof.dr. M.A.G.J. Orrit

PhD Defence

PhD Defence

PhD Defence

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

Parassign is a program to assign protein nuclei solely on the basis of pseudocontact shifts (PCS). The PCS from several paramagnetic tags are required, in order to produce several restraints per nucleus.

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Lecture

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

ALMA has observed stars like the Sun at a very early stage in their formation and found traces of methyl isocyanate - a chemical building block of life. This is the first ever detection of this prebiotic molecule towards solar-type protostars, the sort from which our Solar System evolved. The discovery…

Observations made with the ALMA telescope in Chile and ESA’s Rosetta mission, have detected the faint molecular fingerprint of methyl chloride in gas, a chemical commonly produced by industrial biological processes on Earth, around both an infant star and a comet. Methyl chloride, also known as Freon-40,…

For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disc surrounding a young star. The discovery reaffirms that the conditions that spawned the Earth and Sun are not unique in the Universe. The results are published…

Science, Leiden Institute of Chemistry (LIC)

New research published in the Journal of Leukocyte Biology suggests that these changes to the behavior of the immune system are persistent and can continue even after diet is improvedAlmost everyone knows that improving your eating habits will most likely improve your health. What most people may not…

First author Rubin Dasgupta, PhD student at the Biophysical Organic Chemistry & Macromolecular Biochemistry groups at the Leiden Institute of Chemistry has made the cover of the June edition of Solid State Nuclear Magnetic Resonance.

The DNA of young people is regulated to express the right genes at the right time. With the passing of years, the regulation of the DNA gradually gets disrupted, which is an important cause of ageing. A study of over 3,000 people shows that this is not true for everyone: there are people whose DNA appears…

An international team of researchers led by Alice Booth (Leiden University, the Netherlands) have discovered methanol in the warm part of a planet-forming disk. The methanol cannot have been produced there and must have originated in the cold gas clouds from which the star and the disk formed. Thus,…

Using the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile, researchers at Leiden Observatory in the Netherlands have for the first time detected dimethyl ether in a planet-forming disc. With nine atoms, this is the largest molecule identified in such a disc to date. It is also a precursor…

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

Lecture

Lecture

Recent publications