Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

The division of Systems Biomedicine and Pharmacology focusses on personalised medicine and the development of novel systems-based approaches in translational and clinical pharmacology.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

PhD Defence

PhD Defence

PhD Defence, Livestream

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…

The objective of the PhD Education and Supervision program is to educate PhD candidates in becoming professionals who are competent to conduct scientific research in the field of the pharmaceutical sciences independently.

PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands

Professor at the School of pharmaceutical sciences, University of Geneva - Switzerland

Live from the ASMS Conference 2015 in Saint Louis: Baljit Ubhi, our Metabolomics Specialist, has a coffee with Rawi Ramautar, Assistant Professor at the Leiden Academic Center for Drug Research.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

PhD Defence

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

LCDS organises monthly seminars for researchers and anyone else interested in Data Science. Each of these meetings is centered around a specific topic or academic field, which we approach from a Data Science perspective.

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Professor at the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria - South Africa

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

Can we link multiple components from herbal extracts with their biological activities?

Emeritus professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

PhD at Leiden University and Bruker - the Netherlands

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

On this page the programme and sessions can be found. The programme will be updated regularly.

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

By analysing the metabolism using big data techniques, we can identify health risks at an earlier stage. Thomas Hankemeier, professor of Analytical Biosciences at the Leiden Academic Centre for Drug Research, explains how that works.

An overview of research projects at the Predictive Pharmacology group.

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

In the Phenomix Medical Delta Field Lab, which was officially opened on Thursday 9 July, scientists, healthcare institutions and businesses work together to develop innovative applications in the field of metabolomics. This research field makes it possible to determine which drugs will be effective…