The Metabolomics Facility of the University of Leiden has brought together two research groups from the Faculty of Science that are well-known for their expertise in two different fields: the Biomedical Metabolomics Facility Leiden, experts in clinical metabolomics and the Natural Products Laboratory,…

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

The ambition of the Analytical BioSciences and Metabolomics group led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies…

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

Science, Leiden Academic Centre for Drug Research (LACDR)

an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The Basics and Applications to Plant Sciences HAS BEEN POSTPONED UNTIL FURTHER NOTICE.

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Ramautar

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

Science, Institute of Biology Leiden (IBL)

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotor: Prof.dr. G.P. van Wezel

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

On Friday 17 April Leiden Mayor Henri Lenferink will officially open the new Metabolomics Facility of Leiden University. The facility’s ultimate goal is to prevent disease and to improve health throughout the human lifespan.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

From a white leather armchair, on which Barack Obama once sat, Dean Michiel Kreutzer opened the academic year. This time not with visitors, but completely corona-proof via a live stream. In a homely setting, Kreutzer spoke with several guests, including Covid-19 researcher Thomas Hankemeier and brand…

Venture capital investors Zeeuws Investerings Fonds and Participatiemaatschapij Oost Nederland have joined forces with national and regional partners to fund development and sales of MIMETAS’ unique 3D disease- and tissue modelling technologies.

In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

The Faculty of Science is pleased to invite you on Friday 17 April to the opening event of the Leiden Metabolomics Facility with a mini symposium.

Which metabolites of sponge are influenced by individual environmental or biological factors?

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Factors affecting galanthamine production in Narcissus

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Researchers from the Plant Ecology and Phytochemistry group at the Institute of Biology Leiden (IBL) received an STW (Stichting Technologische Wetenschappen) grant for applied studies in plant herbivore resistance with potential for a novel resistance test.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi