Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

The Metabolomics Facility of the University of Leiden has brought together two research groups from the Faculty of Science that are well-known for their expertise in two different fields: the Biomedical Metabolomics Facility Leiden, experts in clinical metabolomics and the Natural Products Laboratory,…

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

The ambition of the Analytical BioSciences and Metabolomics group led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies…

an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering…

Science, Leiden Academic Centre for Drug Research (LACDR)

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

Ramautar

The Basics and Applications to Plant Sciences

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

Which metabolites of sponge are influenced by individual environmental or biological factors?

The main purpose of pharmacokinetic-pharmacodynamic (PKPD) modelling is the prediction of in vivo time courses of drug effect to optimize translational drug development.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. G.P. van Wezel

Science, Leiden Academic Centre for Drug Research (LACDR), BioMedical Metabolomics Facility Leiden

On Friday 17 April Leiden Mayor Henri Lenferink will officially open the new Metabolomics Facility of Leiden University. The facility’s ultimate goal is to prevent disease and to improve health throughout the human lifespan.

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

PhD Defence, Livestream

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Venture capital investors Zeeuws Investerings Fonds and Participatiemaatschapij Oost Nederland have joined forces with national and regional partners to fund development and sales of MIMETAS’ unique 3D disease- and tissue modelling technologies.

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.

In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

The Faculty of Science is pleased to invite you on Friday 17 April to the opening event of the Leiden Metabolomics Facility with a mini symposium.

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Researchers from the Plant Ecology and Phytochemistry group at the Institute of Biology Leiden (IBL) received an STW (Stichting Technologische Wetenschappen) grant for applied studies in plant herbivore resistance with potential for a novel resistance test.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

The Metabolomics Facility of Leiden University is now officially in operation to prevent disease and to improve health throughout the human lifespan.

On 10 March 2017, Professor Karel Luyben (TU Delft) welcomed the ‘Metabolomics GO FAIR Implementation Network’ as community initiative to start the European Open Science Cloud. The network aims to implement the FAIR data principles in the field of metabolomics in Europe.

Miranda van Eck is benoemd tot hoogleraar Cardio Vascular & Metabolomic Therapeutics bij het Leiden Academic Center for Drug Research (LACDR) van de faculteit der Wiskunde en Natuurwetenschappen. De benoeming ging per per 1 februari 2014 in.