Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

Why do plants produces always produced so many slightly differing metabolites within a particular chemical class?

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

Promotor: Prof.dr. G.P. van Wezel

An interdisciplinary cultural analysis of how the Hindustani double migration informs contemporary processes of identification and problematises the juxtaposition of tradition and modernity.

PNAS publication on protein encounter complexes

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Due to the corona pandemic the 12th International Metabolomics Workshop has been postponed. The event will not take place from March 30 to April 17 2020. We will inform you via this website as soon as we have a new date.

Which metabolites of sponge are influenced by individual environmental or biological factors?

The most commonly used method for the taxonomic identification of tree trunks is wood anatomy. The number of experts in this area is decreasing, and education to become an wood anatomists takes many years. With the help of technology computer scientists of the Leiden Institute of Advanced Computer Science…

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Science, Institute of Biology Leiden (IBL)

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

The Basics and Applications to Plant Sciences will be held online. See below for more information.

The ambition of the Analytical BioSciences and Metabolomics group led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies…

Remko Offringa, Associate Professor in Plant Developmental Genetics, and Associate Professor in Molecular Microbiology Arthur Ram both have been appointed as the new Directors of Education at the IBL. Offringa in the role as Director of Education for the Master program and Ram as Director for the Bachelor…

Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.

Which plant leaf characteristics are involved in thrips resistance in tomato?

- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?

When did the Mali Empire disintegrate? What does the Sunjata heritage demonstrate about the political situation after 1600?