The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

Science, Institute of Biology Leiden (IBL)

Which metabolites of sponge are influenced by individual environmental or biological factors?

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Cardiovascular disease is the leading cause of death worldwide.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: Prof.dr. E. Deprettere

In 2019, Aliaksandr Lukashenka marks a quarter of a century as the first, and so far only president of the Republic of Belarus. This new book by Dr. Matthew Frear, Assistant Professor of Russian and Eurasian Studies, offers the most up-to-date analysis of government and politics in a country usually…

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Developing methodes to understand the evolution of patches in natural ecosystems

Research has shown that the impact of feedback can be very powerful on second language acquisition. However, how to provide adaptive feedback on speaking skills in foreign languages and how to provide differentiated support in secondary schools in regular secondary schools classes of often 25-30 students?…

Brendan Carroll promoted On Thursday October 30th Brendan Carroll successfully defended his PhD dissertation entitled:

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Promotor: P.M. Brakefield

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

Our world may seem unpredictable and uncertain, especially when others are involved. When interacting with others, we cannot know for sure what they may be thinking or planning to do, but we do a good job guessing. This may not be so easy for everyone…

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

What practical knowledge do mentor teachers have of adaptive mentoring and of individual differences between student teachers?

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

High throughput microscopy

Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.

In this article, Makszin developed a conceptual framework for the operating mission of an independent Central Bank and traced changes in the operating mission of the Hungarian National Bank over its recent 27-year history together with Sebők and Simons. This study aims to understand the dynamics of…

The main question I want to answer is about the mutual influence between the cultural and settlements changes that occurred between the Bronze and the Early Iron Age in Margiana and the management of water resources.

How do cognitive, motivational, and affective processes interact to select actions?

What are the functions of autophagy in the filamentous fungus Aspergillus niger?